摘要
目的:探讨红外肝病治疗仪联合抗病毒治疗及强肝丸对老年慢性乙型肝炎(CHB)患者血清细胞因子、肝纤维化的影响。方法:以2020年12月至2021年12在我院门诊收治的107例老年CHB患者为研究对象,根据治疗方法将患者分为两组,观察组53例和对照组54例。对照组患者采用口服抗病毒药及强肝丸治疗,观察组患者在对照组治疗基础上加用红外肝病治疗仪。比较两组患者的临床疗效、血清学及病毒学指标、肝功能指标、肝纤维化指标、血清细胞因子及不良反应发生率。结果:观察组患者临床总有效率为92.5%,明显高于对照组75.9%,差异有统计学意义(P<0.05)。治疗后,相比对照组,观察组ALT复常率、HBV DNA转阴率及HBeAg转阴率明显更高(P<0.05)。观察组治疗后血清ALT、AST、TBil水平比对照组治疗后更低(P<0.05)。相比对照组,观察组血清LN、HA、PCⅢ、Ⅳ-C水平更低(P<0.05)。相比于对照组,观察组血清TGF-β1、IL-6、TNF-α水平均明显更低(P<0.05)。两组不良反应发生率无统计学差异(P>0.05)。结论:在抗病毒治疗及强肝丸基础上加用红外肝病治疗仪对老年CHB患者能取得更好的临床效果,能有效促进相关血清学及病毒学指标转阴,改善肝功能及肝纤维化指标,并降低相关炎性因子水平。
Objective:To investigate the effects of infrared liver disease therapeutic apparatus combined with anti-virus treatment and Qianggan pill on serum cytokines and liver fibrosis in elderly patients with chronic hepatitis B(CHB).Methods:A total of 107 elderly patients with CHB admitted to our outpatient department from December 2020 to December 2021 were selected for study.The patients were randomly divided into two groups,53 cases in the observation group and 54 cases in the control group.The control group was treated with antiviral therapy and Qianggan pill,while the observation group was treated with an infrared liver disease treatment instrument on the basis of the control group.The clinical efficacy,serological and virological indicators,liver function indicators,liver fibrosis indicators,serum cytokines,and the incidence of adverse reactions were compared.Results:The total effective rate of core symptoms after treatment was 92.5%in the observation group,significantly higher than 75.9%in the control group(P<0.05).After treatment,compared with the control group,the ALT normalization rate,HBV DNA negative rate,and HBeAg negative rate were significantly higher in the observation group(P<0.05).Compared with the control group,the levels of serum ALT,AST,and TBil in the observation group were lower(P<0.05).Compared with the control group,the serum LN,HA,PCⅢ,andⅣ-C levels in the observation group were lower(P<0.05).Compared with the control group,the serum levels of TGF-β1,IL-6,and TNF-αin the observation group were significantly lower(P<0.05).The incidence of adverse reactions between the two groups had no statistical difference(P>0.05).Conclusion:On the basis of antiviral therapy and Qianggan pill,infrared liver disease therapeutic instrument can achieve better clinical effects on elderly patients with CHB,effectively promote the serological and virological indicators to turn negative,improve liver function and liver fibrosis indicators,and reduce relevant inflammatory factors.
作者
史娜
宋娟丽
尹玉红
王静
SHI Na;SONG Juan-li;YIN Yu-hong(Fourth Department of Liver Disease,the Infectious Disease Hospital of Handan,Hebei Province,Handan Hebei,056002,China;不详)
出处
《中西医结合肝病杂志》
CAS
2024年第1期16-19,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
邯郸市科学技术研究与发展计划课题(No.1723208006ZC)。
关键词
红外肝病治疗仪
抗病毒
强肝丸
慢性乙型肝炎
infrared liver disease treatment instrument
antivirus
Qianggan pill
chronic hepatitis B
