摘要
目的:通过文献分析探析绝经后骨质疏松症(Postmenopausal Osteoporosis,PMOP)与中医体质类型相关研究的现状,以期从中医体质的角度为防治PMOP提供一定的循证依据。方法:计算机检索PubMed、CBM、中国知网等7个数据库中公开发表的PMOP与中医体质的相关研究。经2名研究人员独立检索、筛选,并对纳入的文献进行质量评价,使用WPS Office软件进行数据提取及Review Manager 5.3软件进行数据综合分析。结果:共检索到222篇文献,最终纳入10篇文献,均为中文文献,其中病例对照研究6篇,横断面研究4篇;总样本量为3 563例,PMOP组样本量为1 961例,骨密度正常的绝经后女性(对照组)样本量为1 602例。病例对照研究中体质类型分布最多的前四位为阳虚质20.48%(229/1 118)、阴虚质16.99%(190/1 118)、气虚质16.19%(181/1 118)、血瘀质12.61%(141/1 118),横断面研究中体质类型分布最多的前四位为阳虚质24.80%(209/843)、阴虚质21.83%(184/843)、气虚质14.35%(121/843)、血瘀质12.69%(107/843),两种不同研究的体质的差异不具有统计学意义(P=0.069);病例对照研究与横断面研究中,PMOP组与对照组中体质类型分布的差异均具有统计学意义(均P <0.001)。基于6篇病例对照研究发现,气虚质、湿热质、气郁质、特禀质的差异无统计学意义(P> 0.05),阳虚质、阴虚质、血瘀质、平和质、痰湿质的差异有统计学意义(P <0.001)。结论:文献归纳综合分析显示,阳虚质、阴虚质、气虚质、血瘀质是PMOP患者的前四种中医体质类型;阳虚质、阴虚质、气虚质、血瘀质是PMOP的危险因素;平和质、痰湿质是PMOP的保护因素。
Objective:To explore the current status of the studies on the correlation between postmenopausal osteoporosis(PMOP)and TCM constitution types through literature analysis,with a view to providing evidence-based basis for the prevention and treatment of PMOP from the perspective of TCM constitution types.Methods:The studies on the correlation between PMOP and TCM constitution types published in seven databases including PubMed,CBM,CNKI,ect.were retrieved by computer.Two researchers independently retrieved and screened the related literature,and evaluated the quality of the included literature.WPS Office software was used for data extraction.Review Manager 5.3 software was used for a data comprehensive analysis.Results:A total of 222 studies were retrieved,and finally 10 studies were included,all of which were in Chinese,including 6 case-control studies and 4 cross-sectional studies.The total sample size was 3563 cases,with 1961 cases in the PMOP group and 1602 postmenopausal women with normal bone mineral density(the ccntrol group).In the case-control study,the top four types of constitution with the highest distribution were Yang deficiency constitution 20.48%(229/1118),Yin(阴)deficiency constitution 16.99%(190/1118),Qi(气)deficiency constitution 16.19%(181/1118),and blood stasis constitution 12.61%(141/1118).In cross-sectional studies,the top four types of constitution with the highest distribution were Yang(阳)deficiency constitution 24.80%(209/843),Yin deficiency constitution 21.83%(184/843),Qi deficiency constitution 14.35%(121/843),and blood stasis constitution 12.69%(107/843).There was no statistically significant difference in TCM constitution types between the two types of studies(P=0.069).There were statistically significant differences in the distribution of TCM constitution types between the PMOP group and the control group(both P<0.001)in both case-control studies and cross-sectional studies.Based on 6 case-control studies,it was found that there was no significant difference in the distribution of Qi deficiency constitution,dampness-heat constitution,Qi stagnation constitution,and inherited-special constitution(all P>0.05),but there was a significant difference in the distribution of Yang deficiency constitution,Yin deficiency constitution,blood stasis constitution,moderate constitution,and phlegmdampness constitution(all P<0.001).Conclusion:The literature comprehensive analysis showed that Yang deficiency constitution,Yin deficiency constitution,Qi deficiency constitution and blood stasis constitution were the top four TCM constitution types in PMOP patients.That Yang deficiency constitution,Yin deficiency constitution,Qi deficiency constitution and blood stasis constitution were the risk factors of PMOP,and that moderate constitution and phlegm-dampness constitution were the protective factors to prevent PMOP.
出处
《中医临床研究》
2023年第32期143-148,共6页
Clinical Journal Of Chinese Medicine
基金
甘肃省中医药管理局项目(GZKP-2020-19)
研究生创新基金项目(2021CX16)。
关键词
绝经后骨质疏松症
中医体质
研究现状
Postmenopausal osteoporosis
TCM constitution
Research status
