摘要
目的观察普拉克索联合左旋多巴治疗帕金森病的效果。方法选取2020年1月—2022年8月湘雅博爱康复医院收治的78例帕金森病患者为研究对象,以随机抽样分组法将患者分为左旋多巴组、联合治疗组,各39例。左旋多巴组予左旋多巴片,联合治疗组在左旋多巴组基础上予盐酸普拉克索片,2组均治疗3个月。比较2组临床疗效,治疗前及治疗3个月后帕金森氏病综合评分量表(UPDRS)、Berg平衡量表(BBS)、抑郁自评量表(SDS)、焦虑自评量表(SAS)、生活质量评分及氧化应激指标(超氧化物歧化酶、谷胱甘肽还原酶、过氧化氢酶),并观察2组不良反应。结果联合治疗组总有效率高于左旋多巴组(97.44%vs.79.49%,χ^(2)=4.522,P=0.033)。治疗3个月后,2组UPDRS评分低于治疗前,BBS评分高于治疗前,且联合治疗组降低/升高幅度大于左旋多巴组(P<0.01);2组SDS、SAS、生活质量评分低于治疗前,且联合治疗组低于左旋多巴组(P<0.01);2组血清超氧化物歧化酶、谷胱甘肽还原酶、过氧化氢酶水平高于治疗前,且联合治疗组高于左旋多巴组(P<0.05或P<0.01)。治疗期间联合治疗组不良反应总发生率为10.26%,与左旋多巴组的5.13%比较,差异无统计学意义(χ^(2)=0.181,P=0.671)。结论普拉克索联合左旋多巴治疗帕金森病的疗效较好,能够更有效地改善患者的运动能力,提高平衡能力,缓解焦虑、抑郁情绪,减轻氧化应激反应,提高生活质量,且安全性较高。
Objective To observe the effect of pramipexole combined with levodopa for Parkinson′s disease.Methods A total of 78 cases of patients with Parkinson′s disease were selected from January 2020 to October 2022 in Xiangya Boai Rehabilitation Hospital,and they were randomly divided into the levodopa group and the combination group,39 cases in each group.Patients in the levodopa group were given levodopa tablets,and patients in the combination group were given pramipexole dihydrochloride tablets,both groups were treated for 3 months.Clinical effect,scores of UPDRS,BBS,SDS,SAS and quality of life,and oxidative stress indexes(superoxide dismutase,glutathione reductase and catalase)before and after 3 months of treatment were compared between the two groups,and adverse reactions were observed.Results Total effective rate of the combination group was higher than that in the levodopa group(97.44%vs.79.49%,χ^(2)=4.522,P=0.033).After 3 months of treatment,UPDRS score in the two groups was lower than that before treatment,BBS score was higher than that before treatment,and the decrease/increase amplitude of indexes in the combination group were greater than those of the levodopa group(P<0.01);Scores of SDS,SAS and quality of life in the two groups were lower than those before treeatment,and the combination group were lower than those in the levodopa group(P<0.01);Serum levels of superoxide dismutase,glutathione reductase and catalase in the two groups were higher than those before treatment,and the combination group were higher than those of the levodopa group(P<0.05 or P<0.01).There was no significant difference of the incidence of adverse reactions during treatment between the combination group(10.26%)and the levodopa group(5.13%)(χ^(2)=0.181,P=0.671).Conclusion Pramipexole combined with levodopa have an exact clinical effect for Parkinson′s disease,it can more effectively improve athletic ability of patients,and promote balanced capacity,relieve anxiety and depression,reduce oxidative stress reaction,improve quality of life,and with high safety.
作者
杨汉文
刘银花
张依蕾
张鸥
杨姣
张燕辉
YANG Hanwen;LIU Yinhua;ZHANG Yilei;ZHANG Ou;YANG Jiao;ZHANG Yanhui(Neurorehabilitation Department,Xiangya Boai Rehabilitation Hospital,Changsha 410000,China;不详)
出处
《临床合理用药杂志》
2024年第3期9-11,15,共4页
Chinese Journal of Clinical Rational Drug Use
关键词
帕金森病
普拉克索
左旋多巴
运动能力
平衡能力
氧化应激
治疗结果
Parkinson′s disease
Pramipexole
Levodopa
Athletic ability
Balanced capacity
Oxidative stress
Treatment outcome
