摘要
本文对近25年国内外延胡索乙素对中枢神经系统的现代研究进行整理归纳,探讨延胡索乙素对中枢神经系统的药理作用及作用机制。延胡索乙素具有镇痛、镇静催眠、镇咳、抗成瘾、抗焦虑和抗抑郁、保护神经活性以及抗癫痫作用,其中镇痛、镇静催眠、镇咳等药理作用在临床上广泛应用,延胡索乙素对中枢神经系统的作用机制清晰,临床疗效确切,具有良好的开发前景。
Objective The article summarized the recent 25 years of domestic modern research on the central nervous system of tetrahydropalmatine on the pharmacological action and mechanism of tetrahydropalma-tine on the central nervous system.Tetrahydropalmatine has analgesic,sedative and hypnotic,antitussive,anti-ad-diction,anti-anxiety and anti-depression,neuroprotective activities and anti-epileptic effects,among which phar-macological effects such as analgesic,sedative and hypnotic,antitussive are widely used in clinical practice.The mechanism of action of tetrahydropalmatine on the central nervous system is clear,the clinical effect is exact,and it has a good development prospect.
作者
张书荣
李奕萱
王艳艳
Zhang Shurong;Li Yixuan;Wang Yanyan(College of Pharmacy,Heilongjiang University of Chinese Medicin,Harbin,Heilongjiang 150040,China)
出处
《中国药物与临床》
2023年第8期477-485,共9页
Chinese Remedies & Clinics
基金
国家自然科学基金(82003974)
国家自然科学基金匹配项目(2020PT01)
黑龙江省自然科学基金(LH2022H086)
黑龙江中医药大学实验中心研究与开发(KY2022-11)
黑龙江中医药大学大学生科技创新项目(KY2023-09)
黑龙江中医药大学创新创业训练计划项目(X202310228021)。
关键词
延胡索乙素
药理作用
中枢神经系统
催眠药和镇静药
抗焦虑药(中药)
抗抑郁药(中药)
Tetrahydropalmatine
Pharmacological action
Central nervous system
Hypnotics and sedatives
Antianxietic(Traditional Chinese medicine)
Antidepressant(Traditional Chinese medicine)
