摘要
目的分析早期生化检验对糖尿病肾病的诊断效果。方法选取43例糖尿病肾病患者为观察组,以同期进行常规体检的72例健康人群为对照组。两组均进行α_(1)微球蛋白(α_(1)-MG)、尿素氮(BUN)、视黄醇结合蛋白(RBP)、C反应蛋白(CRP)、胱抑素C(CysC)、同型半胱氨酸(Hcy)、血清肌酐(SCr)、微量白蛋白(mAlb)等生化指标检验。对比两组生化指标检验结果,分析糖尿病肾病患者生化指标检验的阳性检出率。结果观察组CRP、CysC、α_(1)-MG、BUN、RBP、Hcy、SCr、mAlb水平分别为(11.53±2.05)mg/L、(2.11±0.49)mg/L、(35.16±8.02)mg/L、(13.62±2.15)mmol/L、(85.16±19.43)mg/L、(20.16±3.92)μmol/L、(175.62±15.23)μmol/L、(42.62±10.35)mg/L,均显著高于对照组的(8.95±1.04)mg/L、(0.96±0.12)mg/L、(10.92±3.61)mg/L、(5.21±1.02)mmol/L、(50.36±10.98)mg/L、(13.26±1.28)μmol/L、(123.61±10.25)μmol/L、(21.16±8.26)mg/L,差异有统计学意义(P<0.05)。糖尿病肾病患者CRP、CysC、α_(1)-MG、BUN、RBP、Hcy、SCr、mAlb单独检验及联合检验阳性检出率分别为62.79%、72.09%、37.21%、58.14%、44.19%、69.77%、86.05%、60.47%、97.67%。各项生化检验联合诊断糖尿病肾病患者可取得较高的阳性检出率。结论早期生化检验应用于糖尿病肾病临床诊断中可取得较高的诊断效能。
Objective To analyze the effect of early biochemical tests on the diagnosis of diabetic nephropathy.Methods 43 cases of diabetic nephropathy patients were selected as the observation group,and 72 healthy subjects who underwent routine physical examination during the same period were selected as the control group.Biochemical indices such asα_(1) microglobulin(α_(1)-MG),blood urea nitrogen(BUN),retinol binding protein(RBP),C-reactive protein(CRP),cystatin C(CysC),homocysteine(Hcy),serum creatinine(SCr)and microalbumin(mAlb)were tested in both groups.The results of biochemical tests of the two groups were compared,and the positive rate of biochemical test in diabetic nephropathy patients was analyzed.Results The levels of CRP,CysC,α_(1)-MG,BUN,RBP,Hcy,SCr and mAlb in the observation group were(11.53±2.05)mg/L,(2.11±0.49)mg/L,(35.16±8.02)mg/L,(13.62±2.15)mmol/L,(85.16±19.43)mg/L,(20.16±3.92)μmol/L,(175.62±15.23)μmol/L and(42.62±10.35)mg/L,which were significantly higher than those of(8.95±1.04)mg/L,(0.96±0.12)mg/L,(10.92±3.61)mg/L,(5.21±1.02)mmol/L,(50.36±10.98)mg/L,(13.26±1.28)μmol/L,(123.61±10.25)μmol/L and(21.16±8.26)mg/L in the control group,and the differences were statistically significant(P<0.05).The positive rates of CRP,CysC,α_(1)-MG,BUN,RBP,Hcy,SCr and mAlb alone and in combination were 62.79%,72.09%,37.21%,58.14%,44.19%,69.77%,86.05%,60.47%and 97.67%.The combination of various biochemical tests in the diagnosis of diabetic nephropathy patients could obtain a higher positive detection rate.Conclusion In the clinical diagnosis of diabetic nephropathy,early biochemical tests can achieve high diagnostic efficiency.
作者
万昊昕
WAN Hao-xin(Nanchang Third Hospital,Nanchang 330009,China)
出处
《中国实用医药》
2024年第1期86-88,共3页
China Practical Medicine
关键词
糖尿病肾病
糖尿病
生化检验
早期
诊断效果
Diabetic nephropathy
Diabetes
Biochemical testing
Early
Diagnostic effect
