摘要
目的:分析甲状腺激素(TH)、促甲状腺激素(TSH)及甲状腺自身抗体联合检测在甲状腺疾病诊断中的价值。方法:选取2021年4月—2022年4月于重庆市涪陵区人民医院确诊为甲状腺疾病的患者120例为研究对象,按照患病类型不同分为研究1、2、3组,各40例;另选取同期健康体检者40例为对照组。采用化学发光免疫分析方法测定TH、TSH、抗甲状腺过氧化物酶自身抗体(anti-TPOAb)、甲状腺球蛋白抗体(TgAb)、抗甲状腺球蛋白抗体(anti-TgAb)水平。比较四组TH、TSH、anti-TPOAb、TgAb、anti-TgAb水平,分析联合检测在甲状腺疾病诊断中的价值。结果:与对照组比较,研究1、2、3组TH、TSH、anti-TPOAb、TgAb、anti-TgAb水平更高;与研究1组比较,研究2、3组TgAb水平更高;与研究2组比较,研究1、3组TH、TSH水平更低,研究3组TgAb水平更高,差异有统计学意义(P<0.05)。联合诊断桥本甲状腺炎的曲线下面积(AUC)为0.845,灵敏度为82.5%,特异度为70.0%,准确度为79.2%;联合诊断甲状腺功能减退症的AUC为0.826,灵敏度为75.0%,特异度为83.8%,准确度为76.7%;联合诊断毒性弥漫性甲状腺肿的AUC为0.928,灵敏度为85.0%,特异度为83.8%,准确度为87.5%。结论:不同类型的甲状腺疾病患者血清TH、TSH、甲状腺自身抗体水平存在差异,联合检测对不同甲状腺疾病具有较高的诊断价值。
Objective:To analyze the value of combined detection of thyroid hormone(TH),thyroid stimulating hormone(TSH)and thyroid autoantibodies in the diagnosis of thyroid diseases.Methods:A total of one hundred and twenty patients diagnosed with thyroid disease in Chongqing Fuling District People's Hospital from April 2021 to April 2022 were selected as the study objects,and were divided into study groups 1,2 and 3 according to different disease types,with forty cases each.Another forty healthy subjects were selected as control group.The levels of TH,TSH,anti-thyroid peroxidase autoantibody(anti-TPOAb),thyroglobulin antibody(TgAb)and anti-thyroglobulin antibody(anti-TgAb)were determined by chemiluminescence immunoassay.The levels of TH,TSH,anti-TPOAb,TgAb and anti-TgAb in the four groups were compared to analyze the value of combined detection in the diagnosis of thyroid diseases.Results:Compared with the control group,the levels of TH,TSH,anti-TPOAb,TgAb and anti-TgAb in study groups 1,2 and 3 were higher;Compared with study group 1,study group 2 and study group 3 had higher TgAb level;Compared with study group 2,study group 1 and 3 had lower TH and TSH levels,and study group 3 had higher TgAb levels,the difference was statistically significant(P<0.05);The area under the curve(AUC)of the combined diagnosis of Hashimoto thyroiditis was 0.845,the sensitivity was 82.5%,the specificity was 70.0%,and the accuracy was 79.2%;The AUC for combined diagnosis of hypothyroidism was 0.826,the sensitivity was 75.0%,the specificity was 83.8%,and the accuracy was 76.7%;The AUC of combined diagnosis of toxic diffuse goiter was 0.928,the sensitivity was 85.0%,the specificity was 83.8%,and the accuracy was 87.5%.Conclusion:The levels of serum TH,TSH and thyroid autoantibodies in patients with different types of thyroid diseases are different,and the combined detection has high diagnostic value for different thyroid diseases.
作者
曹莉
汤青明
Cao Li;Tang Qingming(Chongqing Fuling District People's Hospital,Chongqing 408000,China)
出处
《中外医药研究》
2023年第22期153-155,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
