摘要
克罗恩病(Crohn’s disease,CD)是一种发病机制复杂的慢性炎症性肠病。近年来,靶向治疗的广泛应用显著改善了CD患者的预后。若能在靶向治疗早期进行疗效评估,将有利于筛选出治疗获益的患者,同时可对治疗无效的患者及时调整治疗方案。超声在CD活动性评估、疗效评价方面具有准确性高、无电离辐射、患者接纳程度高的优势,在CD早期疗效评估方面具有潜在临床应用价值。本文就超声在CD靶向治疗早期疗效评估中的应用进行综述,以期为优化CD患者的治疗方案提供借鉴。
Crohn's disease(CD) is a chronic inflammatory bowel disease with complicated pathogenesis and prolonged condition.In recent years,with the development of targeted therapy,biological agents have been widely used in the treatment of CD,which has significantly improved the prognosis of CD patients.If the efficacy evaluation can be carried out at the early stage of targeted therapy,it may help to figure out the patients who can benefit from the treatment and optimize the treatment plan for the ineffective patients in time.In the evaluation of CD activity and efficacy,ultrasound has the advantages of high accuracy,no radiation and high patient acceptance,and therefore has potential clinical application value in the early efficacy evaluation of CD targeted therapy.This article reviews the research progress to provides a reference for optimizing the treatment plan for CD patients.
作者
秦菁
朱庆莉
QIN Jing;ZHU Qingli(Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of Ultrasound,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)
出处
《协和医学杂志》
CSCD
北大核心
2024年第1期130-134,共5页
Medical Journal of Peking Union Medical College Hospital
基金
中央高水平医院临床科研专项(2022-PUMCH-C-018)
国家自然科学基金(81791640)。
关键词
超声
早期疗效
克罗恩病
靶向治疗
ultrasonography
early efficacy
Crohn's disease
targeted therapy
