摘要
目的研究咳嗽变异性哮喘(CVA)患儿标准治疗后停药一年复发的影响因素及其交互效应。方法回顾性分析2018年1月-2020年1月玉林市红十字会医院收治的167例CVA患儿的临床资料,所有患儿均接受吸入性糖皮质激素(ICS)规范治疗(疗程≥6个月),停药后随访观察≥2年,按照患儿2年的随访结果,将CVA标准治疗后停药1年复发的98例患儿纳为CVA复发组,69例未复发纳为CVA未复发组,进行对照研究,分析CVA复发影响因素及其交互效应。结果单因素分析得出两组患儿反复呼吸道感染病史、变应性鼻炎、过敏性皮炎及停药时呼出气一氧化氮(FeNO)比较,差异有统计学意义(P<0.05)。多因素分析得出,有反复呼吸道感染病史(OR=4.543,P=0.001)、有变应性鼻炎(OR=7.146,P<0.001)、FeNO>20.00 ppb(OR=3.770,P=0.001)为CVA标准治疗后停药一年复发独立危险因素。反复呼吸道感染病史与变应性鼻炎、反复呼吸道感染病史与FeNO、变应性鼻炎与FeNO的交互作用指数S分别为2.152、1.527、1.397。结论有反复呼吸道感染、变应性鼻炎和FeNO>20.00ppb均是影响CVA标准治疗后停药1年复发的影响因素,且两两因素间有正向交互作用。
Objective To study the influencing factors and their interaction on the recurrence of cough variant asthma(CVA)one year after standard treatment withdrawal in children.Methods The clinical data of 167 children with CVA admitted to Yulin Red Cross Hospital from January 2018 to January 2020 were retrospectively analyzed.All children received standard treatment with inhaled corticosteroids(ICS)(course of treatment≥6 months),and were followed up for≥2 years after drug withdrawal.A total of 98 children who relapsed one year after standard CVA treatment withdrawal were included in the CVA recurrence group,and 69 children who did not relapse were included in the CVA non-recurrence group.A control study was conducted to analyze the influencing factors of CVA recurrence and their interaction effects.Results Single factor analysis showed that the history of recurrent respiratory tract infection,allergic rhinitis,allergic dermatitis and exhaled nitric oxide(FeNO)were significantly different between the two groups(P<0.05).Multivariate analysis showed that the history of recurrent respiratory tract infection(OR=4.543,P=0.001<0.05),allergic rhinitis(OR=7.146,P<0.001),and FeNO>20.00 ppb(OR=3.770,P=0.001<0.05)were independent risk factors for CVA recurrence after 1 year of drug withdrawal.The interaction index S of history of recurrent respiratory infection and allergic rhinitis,history of recurrent respiratory infection and FeNO,and allergic rhinitis and FeNO were 2.152,1.527,and 1.397,respectively.Conclusion Recurrent respiratory infections,allergic rhinitis,and FeNO>20.00ppb are all influencing factors for recurrence after discontinuation of CVA standard treatment for 1 year,and there is a positive interaction between the two factors.
作者
马晓红
曹赋
欧远贵
邓燕艺
MA Xiaohong;CAO Fu;OU Yuangui;DENG Yanyi(Department of Pediatrics,Yulin Red Cross Hospital,Yulin,Guangxi 537000,China;Department of Respiratory Medicine,Yulin Red Cross Hospital,Yulin,Guangxi 537000,China)
出处
《临床肺科杂志》
2024年第2期195-201,共7页
Journal of Clinical Pulmonary Medicine
基金
玉林市科学研究与技术开发计划项目合同(玉市科20212220)。
关键词
小儿咳嗽变异性哮喘
复发
影响因素
交互效应
cough variant asthma in children
relapse
influencing factors
interaction effect
