摘要
目的了解青海地区家庭内成员幽门螺杆菌(H.pylori)感染情况并分析其危险因素。方法横断面研究。将青海地区按照城区、农业区、牧业区分层,选择西宁市城区、海东市农业区、海北藏族自治州牧区。对以上地区2021年至2022年进行健康体检的396个居民家庭(1131人)纳入调查研究。对其进行问卷调查,并采用13C-尿素呼气试验检测H.pylori感染情况。计数资料以例数和百分数表示,采用卡方检验比较各组人群及家庭H.pylori感染率的差异。H.pylori感染的危险因素分析采用多因素logistic回归。P<0.05为差异有统计学意义。结果青海地区H.pylori感染率为52.8%(597/1131),家庭内H.pylori感染率为80.6%(319/396)。对H.pylori阳性家庭的夫妻感染情况分析显示,夫妻一方感染家庭占40.4%(36/89),夫妻双方均感染家庭占59.6%(53/89)。父母感染H.pylori时子女感染情况分析显示,父子均感染家庭占20.0%(9/45),母子均感染家庭占48.9%(22/45),父母子均感染家庭占31.1%(14/45)。单因素分析结果显示,家庭共同生活人数不同,家庭H.pylori感染率总体比较差异有统计学意义(χ^(2)=11.12,P=0.004),组间比较提示共同生活人数为4~5人及5人以上的家庭H.pylori感染率高于共同生活人数为2~3人的家庭。家庭聚餐时不使用公筷、公勺的家庭H.pylori感染率高于使用公筷、公勺的家庭(χ^(2)=6.12,P=0.013)。多因素logistic回归分析结果显示,家庭共同生活人数及家庭聚餐时是否使用公筷、公勺与H.pylori感染相关(P<0.05)。结论青海地区家庭内H.pylori感染率较高,存在明显的家庭聚集现象。其中夫妻同时感染情况比较普遍,且母亲感染H.pylori时对子女感染的影响较大。聚餐时使用公筷、公勺的家庭H.pylori感染率较低,家庭共同生活人数越少,H.pylori感染率越低。
Objective To investigate the prevalence of Helicobacter pylori infection among family members,and analyze associated risk factors.Methods The current investigation was a cross-sectional study.The Qinghai region was stratified into urban areas,agricultural areas,and pastoral areas.The urban areas of Xining City,the agricultural areas of Haidong City,and the pastoral areas of Haibei Tibetan Autonomous Prefecture were selected.A total of 396 resident families(1131 people)who underwent health checkups from 2021 to 2022 in the above areas were included in the survey study.Questionnaires were administered and H.pylori infection was detected using the 13C-urea breath test.Numerical data were expressed as cases and percentages,and the Chi-square test was used to compare differences in H.pylori infection rates in the populations and families in each group.Multifactorial logistic regression was used to analyze risk factors for H.pylori infection,and P<0.05 was considered statistically significant.Results The prevalence of H.pylori infection in Qinghai province was 52.8%(597/1131)and the prevalence of H.pylori infection in households was 80.6%(319/396).In H.pylori-positive households with at least 1 infected spouse,40.4%(36/89)had only 1 infected spouse,and in 59.6%(53/89)both spouses were infected.In analysis of children infected by parents with H.pylori,20.0%(9/45)of households had fathers and children infected,48.9%(22/45)had mothers and children infected,and 31.1%(14/45)had both parents and children infected.In univariate analysis there was a statistically significant difference in the overall comparison of H.pylori infection rates among families with different numbers of people living together(χ^(2)=11.12,P=0.004),and between-group comparisons suggested that H.pylori infection rates were higher in families with 4 or 5 people and more than 5 people living together than in families with 2 or 3 people living together.The H.pylori infection rate was higher in families that did not use serving chopsticks and spoons during family meals than in families that did use serving chopsticks and spoons(χ^(2)=6.12,P=0.013).In multifactorial logistic regression analyses the number of people living together in a family and whether or not serving chopsticks and spoons were used at family meals were associated with H.pylori infection(P<0.05).Conclusion The H.pylori infection rate in families in Qinghai Province is high,and there is a clear association with family aggregation.It is more common for both members of a couple to be infected,and H.pylori infection of a mother has a greater effect on the children′s infection status than H.pylori infection of a father.The infection rate of H.pylori was lower in families that used serving chopsticks and spoons during dinner gatherings,and the fewer the number of people living together in the family,the lower the H.pylori infection rate.
作者
李春霞
王学红
马臻棋
绽永华
沈利娟
王芳
李源化
Li Chunxia;Wang Xuehong;Ma Zhenqi;Zhan Yonghua;Shen Lijuan;Wang Fang;Li Yuanhua(College of Clinical Medicine,Qinghai University,Xining 810016,China;Department of Gastroenterology,the Affiliated Hospital of Qinghai University,Xining 810012,China)
出处
《中华内科杂志》
CAS
CSCD
北大核心
2024年第1期41-45,共5页
Chinese Journal of Internal Medicine
基金
青海省省级临床重点专科建设项目(2022-118)
青海省消化系统疾病临床医学研究中心(2019-SF-L3)。
关键词
螺杆菌
幽门
家庭卫生
流行病学
Helicobacter pylori
Family health
Epidemiology
