摘要
伪狂犬病是由伪狂犬病病毒(pesudorabies virus,PRV)感染引起的一种严重的传染性病毒病,主要引起猪的繁殖失败、生长停滞和呼吸系统障碍,2周龄以下仔猪死亡率高达100%。伪狂犬病属于多种动物共患传染病,主要经口、鼻感染,通过在上呼吸道上皮细胞中的复制,进一步感染神经系统和内脏器官。PRV有11种糖蛋白分子,在病毒的毒力、感染入侵和致病过程中发挥重要作用。临床上采用疫苗免疫和鉴别诊断相结合的方式进行PRV的防控,起到了一定的效果,但是仍然给养猪业造成巨大损失。因此,本文综述和讨论了猪伪狂犬病的临床症状以及病原的分子特征、致病机制和疫苗研究的最新进展,以期为该病疫苗研究和诊断试剂开发提供参考。
Pseudorabies is a serious infectious viral disease caused by pseudorabies virus(PRV),which mainly causes reproductive failure,growth arrest and respiratory disorders in pigs.The mortality of inflicted piglets under 2 weeks old is as high as 100%.PRV infects through the mouth and nose,and further infects the nervous system and internal organs by replicating itself in the epithelial cells of the upper respiratory tract.PRV has 11 glycoprotein molecules,which play an important role in the viral virulence,infection,invasion and pathogenesis of the virus.In clinic practice,the combination of vaccine immunization and differential diagnosis is generally used to prevent and control PRV,which has achieved certain results,but the disease still causes huge losses to the pig industry.Therefore,this paper summarizes and discusses the latest progress in research on the virus in terms of clinical symptoms,molecular characteristics,pathogenic mechanism and vaccine development,in order to provide reference for PRV vaccine research and diagnostic reagent development.
作者
刘运超
杨素珍
尚延丽
郝慧芳
LIU Yunchao;YANG Suzhen;SHANG Yanli;HAO Huifang(Henan Province Key Laboratory of Animal Immunology,Henan Academy of Agricultural Sciences,Zhengzhou 450002,China)
出处
《畜牧与兽医》
CAS
北大核心
2024年第2期124-130,共7页
Animal Husbandry & Veterinary Medicine
基金
河南省重点研发与推广专项(232102110080)
河南省农业科学院自主创新项目(2023ZC085,2023ZC088)。
关键词
伪狂犬病病毒
分子特征
致病机制
疫苗
porcine pseudorabies virus
molecular characteristics
pathogenesis
vaccine
