摘要
多囊卵巢综合征(polycystic ovary syndrome,PCOS)是一种以雄激素过多、排卵功能障碍和多囊卵巢为特征的代谢紊乱性生殖内分泌疾病[1]。根据全国临床大数据流行病调查显示,该病在育龄女性中的发病率为5.6%,其中无排卵性不孕的女性占75%,是引起育龄女性无排卵性不孕的主要原因[2]。
Polycystic ovary syndrome(PCOS)is characterized by high heterogeneity and heredity,and its exact pathogenesis is still not clear.Some studies have shown that epigenetic disorders,such as hyperandrogen-induced methylation or acetylation of lysine at different sites(K4,K9,and K27)in histone H3,methylation and demethylation modification of genes related to steroids,hormone receptors and follicular development,and transcriptional control of microRNA or long noncoding RNA,play a central role in the occurrence and development of PCOS.This article reviews the research advances in epigenetic mechanisms(histone modifications,DNA methylation,and noncoding RNA)of PCOS,in order to provide a reference for the prediction and early prevention of PCOS.
作者
梁梦梦
赵燕
张艳新
邵欣欣
陈聪
郝文庆
LIANG Mengmeng;ZHAO Yan;ZHANG Yanxin;SHAO Xinxin;CHEN Cong;HAO Wenqing(School of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Jinan Center for Disease Control and Prevention,Jinan 250021,China;Academy of Chinese Medicine Literature and Culture,Key Laboratory of Classical Theory of Traditional Chinese Medicine,Ministry of Education,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;First School of Clinical Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Juye County Chinese Medicine Hospital,Juye 274900,China)
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2024年第1期164-171,共8页
Chinese Journal of Pathophysiology
基金
国家科技部重点研发计划项目(No.2017YFC1702700)
山东省中医药科技项目(No.2021Q077)
山东中医药大学中医典籍传承青年科研创新团队(No.22202135)
济南市科技型中小企业创新能力提升工程项目。
