期刊文献+

结肠癌患者miR-148a-3p、miR-19a表达及与预后的关系

Expressions of miR-148a-3p and miR-19a in patients with colon cancer and their relation-ship with prognosis
下载PDF
导出
摘要 目的探究结肠癌患者miR-148a-3p、miR-19a表达及其与预后的关系。方法选择2019年1月至2020年1月于郑州大学人民医院就诊的98例结肠癌患者作为观察组,并选择同期于本院进行体检且结果为健康者49例作为对照组。收集所有研究对象入组时的一般资料;比较两组患者血清miR-148a-3p、miR-19a表达量;比较不同临床特征患者的miR-148a-3p、miR-19a表达;随访患者生存时间,采用单因素生存分析Kaplan-Meier绘制生存曲线,COX风险比例回归分析影响患者预后的因素。结果观察组血清miR-148a-3p表达量显著低于对照组,差异有统计学意义(t=2.669,P<0.05),miR-19a的表达量显著高于对照组,差异有统计学意义(t=2.929,P<0.05);结肠癌患者miR-148a-3p、miR-19a表达水平与肿瘤分化程度、TNM分期有关(t=4.075、2.110,P<0.05);miR-148a-3p低表达患者3年总生存率和3年无病生存率均显著低于高表达患者(χ^(2)=6.978,8.025,P<0.05);miR-19a高表达患者3年总生存率和3年无病生存率均显著低于低表达患者(χ^(2)=8.252,4.474,P<0.05);miR-148a-3p下调、miR-19a上调为影响结肠癌患者3年无病生存率的独立危险因素(P<0.05)。结论结肠癌患者血清miR-148a-3p异常低表达,miR-19a异常高表达,且其异常表达可降低患者3年总生存率和无病生存率。 Objective To explore the expressions of microRNA(miR)-148a-3p and miR-19a,and their relationship with prognosis in patients with colon cancer.Methods A total of 98 patients with colon cancer and 49 healthy controls in People's Hospital of Zhengzhou University were enrolled as the observation group and the control group from January 2019 to January 2020,respectively.The general data of all objects were collected and enrollment.The expression levels of serum miR-148a-3p and miR-19a were compared between the two groups and among patients with different clinical characteristics.The survival time of patients was followed up.The survival curves were drawn by Kaplan-Meier analysis.The influencing factors of prognosis were analyzed by COX proportional hazard regression.Results The expression level of serum miR-148a-3p in the observation group was significantly lower than that in the control group(t=2.669,P<0.05),while miR-19a was significantly higher than that in the control group(t=2.929,P<0.05).The expression levels of miR-148a-3p and miR-19a were correlated with the degree of tumor differentiation and TNM stage(t=4.075,2.110,P<0.05).The 3-year overall survival rate and 3-year disease-free survival rate in patients with low ex-pression of miR-148a-3p were significantly lower than those with high expression(χ^(2)=6.978,8.025,P<0.05).The 3-year overall survival rate and disease-free survival rate in patients with high expression of miR-19a were significantly lower than those with low expression(χ^(2)=8.252,4.474,P<0.05).Downregulated of miR-148a-3p and upregulated of miR-19a were independent risk factors affecting the 3-year disease-free survival rate of patients with colon cancer(OR=0.024,2.642,P<0.05).Conclusion Patients with colon cancer have abnor-mally low expression of serum miR-148a-3p and abnormally high expression of miR-19a,and their abnormal expression can reduce the patient's 3-year overall survival rate and disease-free survival rate.
作者 胡敏 牛雅轩 王瑾琳 陈晓 崔发财 HU Min;NIU Yaxuan;WANG Jinlin;CHEN Xiao;CUI Facai(Department of Laboratory Medicine,Henan Provincial People's Hospital,Zhengzhou University People's Hospital,Zhengzhou,Henan,China,450000)
机构地区 河南省人民医院
出处 《分子诊断与治疗杂志》 2023年第12期2147-2150,2154,共5页 Journal of Molecular Diagnostics and Therapy
基金 河南省科技攻关项目(20210231010325)。
关键词 结肠癌 miR-148a-3p miR-19a 生存率 Colon cancer MiR-148a-3p MiR-19a Survival rate
  • 相关文献

参考文献12

二级参考文献46

  • 1钟文,肖烈钢,易瑶,钟海林,谢栋.miR-4295在鼻咽癌细胞增殖中的作用[J].热带医学杂志,2019,19(11):1343-1347. 被引量:3
  • 2Eis PS, Tam W, Sun L, et al. Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci U S A, 2005,102(10) :3627-3632.
  • 3Yanaihara N, Caplen N, Bowman E, et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell ,2006,9 ( 3 ) : 189-198.
  • 4Vofinia S, Calin GA, Liu CG, et al. A microRNA expression sig- nature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A,2006,103(7) :2257-2261.
  • 5Xi Y, Fonnentini A, Chien M, et al. Prognostic Values of micro- RNAs in Colorectal Cancer. Biomark Insights,2006,2:113-121.
  • 6Yan LX, Huang XF, Shao Q, et al. MicroRNA miR-21 overex- pression in human breast cancer is associated with advanced clini- cal stage, lymph node metastasis and patient poor prognosis. RNA ,2008,14 ( 11 ) :2348-2360.
  • 7Nikiforova MN, Tseng GC, Steward D, et al. MicroRNA expres- sion profiling of thyroid tumors: biological significance and diag- nostic utility. J Clin Endocrinol Metab,2008,93 (5) :1600-1608.
  • 8Wang X, Tang S, Le SY, et al. Aberrant expression of onogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth. PLoS One,2008,3 (7) :e2557.
  • 9Bloomston M, Frankel WL, Petrocca F, et al. MicroRNA expres- sion patterns to differentiate pancreatic adenocarcinoma from nor- mal pancreas and chronic pancreatitis. JAMA, 2007,297 ( 17 ) : 1901-1908.
  • 10Gironella M, Seux M, Xie MJ, et al. Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its res- toration inhibits pancreatic tumor development. Proc Nail Acad Sei U S A.2007,104(41) :16170-16175.

共引文献1463

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部