摘要
目的:探究双歧杆菌三联活菌胶囊联合匹维溴铵在肠易激综合征患者中的应用效果及对肛肠动力学的影响。方法:选择2020年6月—2022年12月中国人民解放军海军第971医院收治的80例肠易激综合征患者,根据随机数字表法分为两组,每组40例。对照组采用匹维溴铵进行治疗,观察组则在对照组的基础上加用双歧杆菌三联活菌胶囊治疗。比较两组治疗总有效率、治疗前后的症状体征积分(腹痛、腹胀及大便性状)、肛肠动力学指标(肛管静息压、肛管收缩压及直肠最大容量)及生存质量[肠易激综合征-生存质量量表(IBS-QOL)]。结果:观察组治疗总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗前两组症状体征积分、肛肠动力学指标及IBS-QOL评分比较,差异均无统计学意义(P>0.05);治疗后观察组症状体征积分、IBS-QOL评分均显著低于对照组,肛管静息压、肛管收缩压及直肠最大容量均显著高于对照组,差异均有统计学意义(P<0.05)。结论:双歧杆菌三联活菌胶囊联合匹维溴铵在肠易激综合征患者中的应用效果较好,可显著改善患者的肛肠动力学,减轻症状体征,提高生活质量。
Objective:To investigate the application effect of Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules combined with Pinaverium Bromide in patients with irritable bowel syndrome and its influence on anorectal dynamics.Method:A total of 80 patients with irritable bowel syndrome admitted to the 971st Hospital of the Chinese People's Liberation Army Navy from June 2020 to December 2022 were selected and divided into two groups according to random number table method,with 40 cases in each group.The control group was treated with Pinaverium Bromide,and the observation group was treated with Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules on the basis of the control group.The total effective rate,symptoms and signs integrations(abdominal pain,abdominal bloating and fecal characteristics),anorectal dynamics indexes(resting anal pressure,anal systolic pressure and maximum rectal volume) and quality of life [irritable bowel syndromequality of life(IBS-QOL)] of the two groups before and after treatment were compared.Result:The total effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in symptoms and signs integrations,anorectal dynamics indexes and IBS-QOL scores between the two groups(P>0.05);after treatment,the symptoms and signs integrations and IBS-QOL scores of the observation group were significantly lower than those of the control group,resting anal pressure,anal systolic pressure and maximum rectal volume were significantly higher than those of control group,the differences were statistically significant(P<0.05).Conclusion:Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules combined with Pinaverium Bromide has a good effect in patients with irritable bowel syndrome,which can significantly improve the anorectal dynamics of patients,reduce symptoms and signs,and improve the quality of life.
作者
苑刚
孙海源
孙波
YUAN Gang;SUN Haiyuan;SUN Bo(Department of Gastroenterology,the 971st Hospital of the Chinese People's Liberation Army Navy,Qingdao 266071,China;不详)
出处
《中国医学创新》
CAS
2024年第3期5-8,共4页
Medical Innovation of China
关键词
双歧杆菌三联活菌胶囊
匹维溴铵
肠易激综合征
肛肠动力学
Live Combined Bifidobacterium
Lactobacillus and Enterococcus Capsules Pinaverium Bromide
Irritable bowel syndrome
Anorectal dynamics
