摘要
目的观察肺腺癌中医证型与诱导痰转化生长因子(TGF)-β、干扰素(IFN)-γ、基质金属蛋白酶9(MMP-9)的关系。方法选取2020年1月至2023年1月临泉县人民医院收治的80例肺腺癌患者作为研究组,并根据研究组中医症型将其分为脾肾阳虚型(A组),气阴两虚型(B组)以及肺脾气虚型(C组),另外选取同期体检健康人群80名作为对照组,比较各组诱导痰TGF-β、IFN-γ、MMP-9水平。结果80例肺腺癌患者中,脾肾阳虚型患者28例(35.00%),气阴两虚型患者26例(32.50%),肺脾气虚型患者26例(32.50%)。研究组患者诱导痰TGF-β、MMP-9水平高于对照组,差异有统计学意义(t=5.793、20.727,P<0.05),诱导痰IFN-γ水平低于对照组,差异有统计学意义(t=6.511,P<0.05)。A组患者诱导痰TGF-β、MMP-9水平高于B组、C组,差异有统计学意义(t=3.704、3.859、5.948、6.290,P<0.05),诱导痰IFN-γ水平及KPS评分低于B组、C组,差异有统计学意义(t=9.391、8.982、2.748、2.282,P<0.05)。B组与C组患者诱导痰TGF-β、IFN-γ、MMP-9水平及KPS评分之间的差异无统计学意义(t=0.269、0.808、0.421、0.376,P>0.05)。pearson相关性结果显示,诱导痰TGF-β、MMP-9水平与KPS评分成负相关(P<0.05),IFN-γ水平与KPS评分成正相关(P<0.05)。结论与气阴两虚型及肺脾气虚型肺腺癌患者相比,脾肾阳虚型患者诱导痰TGF-β及MMP-9水平较高,IFN-γ水平较低,且三者均与KPS评分具有相关性,可作为肺腺癌中医辨证的辅助指标。
Objective To observe the relationship between traditional Chinese medicine syndrome types of lung adenocarcinoma and transforming growth factor(TGF)-β,interferon(IFN)-γand matrix metalloproteinase-9(MMP-9)in induced phlegm.Methods Eighty patients with lung adenocarcinoma admitted to the hospital from January 2020 to January 2023 were selected as the study group.They were divided into group A(spleen-kidney yang deficiency pattern),group B(qi-yin deficiency pattern)and group C(spleen-lung qi deficiency pattern)based on TCM syndrome types.At the same time,80 healthy individuals were selected as the control group.The levels of TGF-β,IFN-γand MMP-9 in induced sputum of different groups were comparatively analyzed.Results Among the 80 patients with lung adenocarcinoma,there were 28(35.00%)cases of spleen-kidney yang deficiency pattern,26(32.50%)cases of qi-yin deficiency pattern and 26(32.50%)cases of spleen-lung qi deficiency pattern.The levels of TGF-βand MMP-9 in induced sputum in the study group were higher than those in the control group(t=5.793,20.727,P<0.05),and the level of IFN-γwas lower than that in the control group(t=6.511,P<0.05).The levels of TGF-βand MMP-9 in induced sputum in group A were higher than those in group B and group C(t=3.704,3.859、5.948,6.290,P<0.05).The lev-el of IFN-γand KPS score were lower than those in group B and group C(t=9.391,8.982,2.748,2.282,P<0.05).There was no statistically significant difference in above-mentioned indicators between group B and group C(t=0.269,0.808,0.421,0.376,P>0.05).Pearson correlation analysis results showed that the levels of TGF-βand MMP-9 in induced sputum were negatively correlated with the KPS score(P<0.05),and the level of IFN-γwas positively correlated with the KPS score(P<0.05).Conclusion Compared with patients with qi-yin deficiency syndrome and spleen-lung qi deficiency syndrome,patients with spleen-kidney yang deficiency syndrome had higher levels of TGF-βand MMP-9,and lower IFN-γlevel in induced sputum.The three indicators are correlated with the KPS score and can be used as auxiliary indicators for Traditional Chinese Medicine syndrome differentiation of lung adenocarcinoma.
作者
刘清清
LIU Qingqing(Department of Oncology,Linquan County People's Hospital,Fuyang,Anhui,China,236400)
出处
《分子诊断与治疗杂志》
2024年第1期68-71,共4页
Journal of Molecular Diagnostics and Therapy
基金
安徽省卫生健康委科研项目(AHWJ2020a091)。
关键词
肺腺癌
中医证型
转化生长因子-Β
干扰素-Γ
基质金属蛋白酶9
Lung adenocarcinoma
Traditional Chinese Medicine syndrome type
Transforming growth factor-β
Interferon-γ
Matrix metalloproteinase 9
