摘要
目的观察针刺联合硫酸羟氯喹对原发性干燥综合征患者辅助性T细胞-17(Th-17)/调节性T细胞(Treg)比率的影响。方法选取2019年12月至2020年12月山西省中医院门诊及住院收治的52例原发性干燥综合征患者作为研究对象,按照随机数字表法分为治疗组(26例)与对照组(26例)。对照组患者给予口服硫酸羟氯喹治疗,治疗组在对照组基础上联合针刺治疗。比较两组临床疗效及治疗前后中医证候积分、泪液流率、唾液流率、红细胞沉降率(ESR)、C反应蛋白(CRP)、血清免疫球蛋白G(IgG)水平及Th17/Treg比率变化。结果治疗组患者治疗后临床总有效率高于对照组,差异有统计学意义(P<0.05)。治疗组患者治疗后中医证候积分低于对照组;泪液流率、唾液流率高于对照组;ESR、CRP、IgG水平低于对照组;Th17/Treg比率低于对照组,差异有统计学意义(P<0.05)。结论针刺联合硫酸羟氯喹治疗原发性干燥综合征患者疗效确切,安全可靠,能明显改善口干、眼干症状,降低免疫反应,可降低中医证候积分,升高泪液流率、唾液流率,降低Th17/Treg比率,调节免疫功能。
Objective To observe the effect of acupuncture combined with Hydroxychloroquine Sulfate(HCQ)on the ratio of T helper cell 17(T-17)/regulatory T cell(Treg)in patients with primary Sjogren's syndrome.Methods A total of 52 patients of primary Sjogren syndrome admitted to Shanxi Chinese Medicine Hospital from December 2019 to December 2020 were selected as the research subjects,and they were divided into treatment group(26 cases)and control group(26 cases)according to random number table.The control group patients were given oral HCQ,while the treatment group patients were treated with acupuncture in addition to the control group.The clinical efficacy and traditional Chinese medicine(TCM)syndrome scores,tear flow rate,saliva flow rate,levels of erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),serum immunoglobulin G(IgG)and Th17/Treg ratio were compared between the two groups before and after treatment.Results The total clinical effective rate of patients in the treatment group after treatment was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the TCM syndrome score of the treatment group was lower than that of the control group;the tear flow rates,saliva flow rates were higher than those of the control group;the levels of ESR,CRP,IgG were lower than those of the control group;and the Th17/Treg ratios was lower than that of the control group,the differences were statistically significant(P<0.05).Conclusion Acupuncture combined with HCQ is effective,safe and reliable in the treatment of patients with primary Sjogren's syndrome.It can significantly improve the symptoms of dry mouth and dry eyes,reduce the immune response,reduce TCM syndrome points,increase the tear flow rate and saliva flow rate,reduce the Th17/Treg ratio and regulate the immune function.
作者
李新华
周晓莉
王超
宋美卿
LI Xinhua;ZHOU Xiaoli;WANG Chao;SONG Meiqing(Department of Acupuncture,Shanxi Chinese Medicine Hospital,Shanxi Province,Taiyuan 030012,China;Department of Rheumatology,Shanxi Chinese Medicine Hospital,Shanxi Province,Taiyuan 030012,China;Department of Rheumatology,Shanxi University of Traditional Chinese Medicine Affiliated Hospital,Shanxi Province,Taiyuan 030012,China;Key Laboratory of Clinical Pharmacology,Shanxi Chinese Medicine Hospital,Shanxi Province,Taiyuan 030012,China)
出处
《中国当代医药》
CAS
2024年第2期106-110,共5页
China Modern Medicine
基金
全国名老中医药传承工作室建设项目(国中医药人教函[2022]75号)。
