摘要
目的分析T细胞水平与社区获得性肺炎患儿病情分度及预后的相关性。方法选取2019年2月—2021年1月在朝阳市第二医院接受治疗的500例社区获得性肺炎患儿作为观察组,按照《儿童社区获得性肺炎管理指南(2013修订)》标准,分为轻症组(464例)和重症组(36例)。根据患儿的最终治疗结局,分为痊愈患儿189例,好转患儿215例,无效患儿96例。另选取同期健康体检儿童500例作为对照组。比较观察组和对照组患儿,不同预后、不同病情分度的观察组患儿的CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)及CD19^(+)水平。研究预后、病情分度与CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)及CD19^(+)水平的相关性。结果观察组CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)及CD19^(+)水平分别为(57.25±2.27)%、(35.34±2.51)%、(27.06±2.57)%、(1.27±0.68)、(27.87±2.01)%,对照组CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)及CD19^(+)水平分别为(76.47±2.87)%、(48.92±1.57)%、(37.06±1.92)%、(1.07±0.74)、(30.45±1.76)%,观察组CD3^(+)、CD4^(+)、CD8^(+)及CD19^(+)水平均显著低于对照组,CD4^(+)/CD8^(+)显著高于对照组,差异均有统计学意义(均P<0.05)。痊愈组、有效组、无效组CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)及CD19^(+)水平比较,差异均有统计学意义(均P<0.05)。重症组患儿的CD3^(+)、CD4^(+)、CD8^(+)和CD19^(+)水平均显著低于轻症组,CD4^(+)/CD8^(+)显著高于轻症组,差异均有统计学意义(均P<0.05)。CD3^(+)、CD4^(+)、CD8^(+)和CD19^(+)水平与预后以及病情分度均呈正相关,CD4^(+)/CD8^(+)与预后以及病情分度均呈负相关(均P<0.05)。结论T细胞水平与社区获得性肺炎患儿病情分度及预后的相关性较强,可作为患儿病情判断的重要依据。
Objective To analyze the correlations between levels of T cells and disease grade and prognosis of children with community-acquired pneumonia.Methods A total of 500 children with community-acquired pneumonia treated in the Second Hospital of Chaoyang City from February 2019 to January 2021 were selected as observation group.According to Management Guidelines for Community-acquired pneumonia in Children(2013 revision),they were divided into mild group(464 children)and severe group(36 children).According to the final treatment outcome,189 children were cured,215 children were improved,and 96 children failed.In addition,500 healthy children were selected as control group during the same period.The levels of CD3^(+),CD4+,CD8^(+),CD4^(+)/CD8^(+),and CD19^(+)were compared between observation group and control group,as well as children in observation group with different prognosis and disease grades.The correlations between prognosis,disease grades and CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+),and CD19 levels were analyzed.Results The levels of CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+),and CD19^(+)in observation group were(57.25±2.27)%,(35.34±2.51)%,(27.06±2.57)%,(1.27±0.68),and(27.87±2.01)%,respectively;the levels of CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+),and CD19^(+)in control group were(76.47±2.87)%,(48.92±1.57)%,(37.06±1.92)%,(1.07±0.74),and(30.45±1.76)%,respectively.The levels of CD3^(+),CD4^(+),CD8^(+),and CD19^(+)in observation group were statistically significantly lower than those in control group,CD4t/CD8 ratio in observation group was statistically significantly higher than that in control group(P<0.05).There were statistically significant differences in the levels of CD3^(+),CD4,CD8^(+),CD4^(+)/CD8^(+),and CD19^(+)among cure group,effective group,and ineffective group(P<0.05).The levels of CD3^(+),CD4^(+),CD8^(+),and CD19^(+)in severe group were statistically significantly lower than those in mild group,CD4^(+)/CD8 ratio was statistically significantly higher than that in mild group(P<0.05).Prognosis and disease grades were positively correlated with CD3^(+),CD4^(+),CD8^(+),and CD19^(+)levels and negatively correlated with CD4^(+)/CD8^(+)ratio(P<0.05).Conclusion The levels of T cells are strongly correlated with the severity and prognosis of community-acquired pneumonia in children,which can be used as an important basis for the judgment of children'condition.
作者
李宗泽
李静
全守东
丁殿帅
LI Zong-ze;LI Jing;QUAN Shou-dong;DING Dian-shuai(Department of Pediatrics,the First Affiliated Hospital of Jinzhou Medical University,Jinzhou,Liaoning 121004,China;Department of Pediatrics,the Second Hospital of Chaoyang City,Chaoyang,Liaoning 122000,China;不详)
出处
《中国妇幼保健》
2024年第1期41-44,共4页
Maternal and Child Health Care of China
基金
辽宁省科学技术计划项目(20180551155)。
关键词
T细胞水平
儿童
社区获得性肺炎
病情分度
预后
相关性
T cell level
Child
Community-acquired pneumonia
Disease grade
Prognosis
Correlation
