摘要
目的分析参麦注射液联合化疗治疗气阴两虚型中晚期肺癌的效果。方法简单随机选取2022年8月—2023年7月曹县人民医院收治的气阴两虚型中晚期肺癌患者90例作为研究对象,按照随机数表法分为对照组与研究组,每组45例。对照组采取化疗治疗,研究组在其基础上联合参麦注射液治疗。针对两组临床疗效,外周血T淋巴细胞分化簇4(cluster of differentiation 4 receptors,CD4^(+))、T淋巴细胞分化簇3(cluster of differentiation 3 receptors,CD3^(+))、T淋巴细胞分化簇8(cluster of differentiation 8 receptors,CD8^(+))水平,以及不良反应予以比较。结果研究组总有效率为55.56%,高于对照组的33.33%,差异有统计学意义(χ^(2)=4.500,P<0.05)。治疗后研究组CD4^(+)、CD3^(+)高于对照组,差异有统计学意义(P<0.05),而两组CD8^(+)比较,差异无统计学意义(P>0.05)。研究组血红蛋白降低、白细胞降低、恶心呕吐、血小板减少发生率均低于对照组,差异有统计学意义(P<0.05),两组肝肾功能损伤、神经毒性发生率对比,差异无统计学意义(P>0.05)。结论在化疗的基础上联合参麦注射液治疗气阴两虚型中晚期肺癌能够有效提高临床疗效,改善患者的免疫功能,抑制化疗不良反应。
Objective To analyze the effect of Shenmai injection combined with chemotherapy in treating middle and advanced lung cancer of Qi-Yin deficiency type.Methods A total of 90 patients with Qi-Yin deficiency type of middle-advanced lung cancer treated in Caoxian People's Hospital from August 2022 to July 2023 were randomly selected as the study objects,and were divided into control group and study group according to random number table method,with 45 cases in each group.The control group was treated with chemotherapy,and the study group was treated with Shenmai injection on the basis of chemotherapy.For the clinical efficacy of the two groups,peripheral blood T lymphocyte cluster of differentiation 4 receptors(CD4^(+)),T lymphocyte cluster of differentiation 3 receptors(CD3^(+)),T lymphocyte cluster of differentiation 8 receptors(CD8^(+))levels,and adverse reactions were compared.Results The total effective rate of the study group was 55.56%,which was higher than that of the control group(33.33%),the difference was statistically significant(χ^(2)=4.500,P<0.05).After treatment,CD4^(+)and CD3^(+)in the study group were higher than those in the control group,the differences were statistically significant(P<0.05),but there was no statistically significant difference in CD8^(+)between the two groups(P>0.05).The incidence of decreased hemoglobin,decreased white blood cells,nausea,vomiting and thrombocytopenia in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of liver and kidney function injury and neurotoxicity between the two groups(P>0.05).Conclusion On the basis of chemotherapy combined with Shenmai injection in the treatment of Qi-Yin deficiency type of middle and advanced lung cancer can effectively improve the clinical efficacy,improve the immune function of patients,inhibit the adverse reaction of chemotherapy.
作者
宋雪薇
张奎松
SONG Xuewei;ZHANG Kuisong(Department of Respiratory and Critical Care Medicine,Caoxian County People's Hospital,Heze,Shandong Province,274400 China)
出处
《世界复合医学》
2023年第11期104-107,共4页
World Journal of Complex Medicine
关键词
参麦注射液
化疗
气阴两虚
中晚期肺癌
Shenmai injection
Chemotherapy
Qi-Yin deficiency
Advanced lung cancer
