摘要
类淋巴系统是中枢神经系统特有网络,该系统可清除大脑积累的代谢废物,维持中枢神经系统的内环境稳态。该系统在睡眠状态下相对活跃,生理功能受到多种因素影响。非侵入性影像技术评估类淋巴系统功能的应用推动了临床研究的开展。越来越多的研究表明,类淋巴系统功能与神经退行性疾病、脑血管病等多种中枢神经系统疾病的发病机制相关。类淋巴系统有望成为预测中枢神经系统疾病预后及临床干预疗效的新靶点。
The glymphatic system is a unique network of the central nervous system that facilitates the removal of metabolic waste from the brain and maintains homeostasis.The glymphatic system is relatively active during sleep,and its physiological function is affected by many factors.The application of non-invasive imaging techniques to evaluate the function of the glymphatic system has promoted the development of clinical studies.More and more studies have demonstrated the association between the function of glymphatic system and the pathogenesis of neurodegenerative diseases,cerebrovascular diseases and other central nervous system diseases.The glymphatic system is expected to become a novel target for predicting prognosis of central nervous system diseases and clinical effects.
作者
赵梦瑶
付一典
梁晓晗
吕小涵
吕佩源
ZHAO Mengyao;FU Yidian;LIANG Xiaohan;LYU Xiaohan;LYU Peiyuan(Hebei General Hospital,Shijiazhuang 050051,China.)
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2023年第11期689-694,共6页
Chinese Journal of Nervous and Mental Diseases
基金
河北省高端人才支持计划(编号:冀办[2019]63号)
河北省政府资助临床医学优秀人才培养项目(编号:冀财社[2019]139号)
河北省科技创新团队(编号:冀政字[2020]9号)
河北省自然科学基金(编号:H2022307075)。
关键词
类淋巴系统
阿尔茨海默病
帕金森病
脑血管病
弥散张量成像
Glymphatic
Alzheimer disease
Parkinson disease
Cerebrovascular disease
Diffusion tensor imaging
