摘要
甲氨蝶呤(methotrexate,MTX)作为一种抗肿瘤药与抗风湿药,在临床有着广泛的应用。MTX毒副作用较多,常见的不良反应有消化道黏膜损伤、中枢神经系统损伤、肝肾功能损伤等。这些毒副作用常常给患者的后续治疗带来很大困扰,明确MTX对各器官毒性的机制成为解救其中毒的关键。该文旨在总结MTX对各器官毒性的作用机制,以便临床发生不良反应时的解救和对其毒性治疗的研究。
As a widely used anti-tumor drug and anti-rheumatic drug in clinic,methotrexate(MTX)has many toxic and side effects,including gastrointestinal mucosa injury,central nervous system injury,liver and kidney function injury,etc.They often bring great trouble to the follow-up treatment of patients.The clarification of the mechanism of MTX toxicity to various organs has become the key to rescue the toxicity.The purpose of the article is to review the toxicity mechanism of MTX in various organs,so as to save the patients from the adverse reactions in clinical treatment.
作者
陈浩
尹连红
彭金咏
CHEN Hao;YIN Lian-hong;PENG Jin-yong(The First Affiliated Hospital,2.School of Pharmaceutical Sciences,Dalian Medical University,Dalian Liaoning 116044,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2024年第2期213-218,共6页
Chinese Pharmacological Bulletin
基金
“兴辽英才计划”科技创新领军人才项目(No XLYC1802121)
辽宁省大学生创新创业训练计划项目(No S202110161007)。
关键词
甲氨蝶呤
器官
毒性
分子机制
叶酸
氧化应激
methotrexate
organ
toxicity
molecular mechanism
folic acid
oxidative stress
