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切口注射曲安奈德预防剖宫产瘢痕增生的效果研究

Effect of Incision Injection of Triamcinolone Acetonide on Prevention of Cesarean Scar Hyperplasia
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摘要 目的:研究曲安奈德切口注射预防剖宫产瘢痕增生的效果。方法:选取2020年3月-2022年6月于笔者医院预接受剖宫产手术的600例产妇,采用随机数字表法分为观察组(n=300)和对照组(n=300)。术中观察组切口两侧局部小剂量曲安奈德皮内注射,对照组切口两侧不实行任何注射,术后常规关闭切口。术后随访6个月,记录两组产妇瘢痕形态、疼痛程度、瘢痕美观度、线结反应、脂肪液化发生情况、局部皮肤症状发生情况及产妇满意度,并进行统计学分析。结果:术后3、6个月,观察组瘢痕长度均短于对照组(P<0.05),温哥华瘢痕量表(Vancouver scar scale,VSS)各评分及总分均低于对照组(P<0.05);术后1、3、6个月,观察组疼痛评分低于对照组(P<0.05);术后6个月,观察组患者瘢痕评价量表(Patient scar assessment scale,PSAS)和观察者瘢痕评价量表(Observer scar assessment scale,OSAS)评分均低于对照组(P<0.05);术后,观察组线结反应、脂肪液化发生率及局部皮肤症状总发生率均低于对照组(P<0.05);观察组产妇总满意率高于对照组(P<0.05)。结论:剖宫产产妇采用曲安奈德切口注射能有效缓解疼痛,改善瘢痕形态,临床效果肯定,不良反应轻微,有助于提高产妇满意度,值得临床推广。 Objective To study the effect of intraoperative injection of triamcinolone acetonide on preventing scar hyperplasia during cesarean section and long-term follow-up.Methods 600 patients who underwent cesarean section in the author's hospital from March 2020 to June 2022 were selected,were divided into observation group(n=300)and control group(n=300)by random number table.During the operation,local low-dose triamcinolone acetonide was injected on both sides of the incision in the observation group,and no injection was performed on both sides of the incision in the control group.The patients were followed up for 6 months,scar shape,degree of pain,scar beauty,suture reaction,occurrence of fat liquefaction,nursing satisfaction and local skin symptoms were recorded.Results At 3 and 6 months after operation,the scar length in the observation group was shorter than that in the control group(P<0.05),and the scores and total score of vancouver scar scale(VSS)in the observation group were lower than those in the control group(P<0.05).At 1,3,and 6 months after operation,the pain score of the observation group was lower than that of the control group(P<0.05).At 6 months after operation,the scores of patient scar assessment scale(PSAS)and observer scar assessment scale(OSAS)in the observation group were lower than those in the control group(P<0.05).After operation,the incidence of knot reaction,fat liquefaction and the total incidence of local skin symptoms in the observation group were lower than those in the control group(P<0.05).The total satisfaction rate of puerpera in the observation group was higher than that in the control group(P<0.05).Conclusion Triamcinolone acetonide injection during cesarean section can effectively improve scar morphology,reduce pain,prevent scar hyperplasia,improve nursing satisfaction,and have mild adverse reactions.It was worthy to be popularized clinically.
作者 周学梅 王少帅 杜婧 邹婧 刘小丽 方秀丽 杨妍 周芳 ZHOU Xuemei;WANG Shaoshuai;DU Jing;ZOU Jing;LIU Xiaoli;FANG Xiuli;YANG Yan;ZHOU Fang(Department of Obstetrics,Xiaogan First People's Hospital,Xiaogan 432099,Hubei,China;Department of Obstetrics and Gynecology,Tongji Hospital Tongji Medical College of Hust,Wuhan 430030,Hubei,China)
出处 《中国美容医学》 CAS 2024年第1期7-10,共4页 Chinese Journal of Aesthetic Medicine
基金 2022年度孝感市自然科学计划立项(编号:XGKJ2022010050)。
关键词 曲安奈德 剖宫产 瘢痕增生 切口 注射 triamcinolone acetonide cesarean section scar hyperplasia incision injection
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