摘要
目的探讨桂枝茯苓丸联合地诺孕素治疗子宫内膜异位症的临床疗效及其对患者子宫内膜受容性的改善作用。方法按治疗方法将2021年5月至2023年5月于南阳医学高等专科学校第一附属医院就诊的138例子宫内膜异位症患者分为对照组(69例)和观察组(69例)。对照组患者施以地诺孕素片口服治疗,观察组在上述基础上联合桂枝茯苓丸口服治疗。比较2组临床疗效,治疗前后体内激素水平、子宫内膜受容性及血清糖类抗原125(CA125)、血管内皮细胞生长因子(VEGF)、丝裂原活化蛋白激酶(MAPK)水平。结果观察组(89.9%)临床疗效较对照组(76.8%)更高(P<0.05)。2组经治疗黄体生成素、雌二醇及促卵泡激素水平均降低,观察组水平较对照组低(P<0.05)。2组经治疗内膜容积均增大,且观察组较对照组大;2组内膜厚度均增加,且观察组更厚;2组血流阻力指数与血流搏动指数均降低,且观察组较对照组低(P<0.05)。2组经治疗血清CA125、VEGF、MAPK水平均降低,且观察组较对照组低(P<0.05)。结论桂枝茯苓丸联合地诺孕素治疗子宫内膜异位症疗效确切,可有效调节患者体内激素水平,增强子宫内膜受容性,调节血清CA125、VEGF、MAPK水平。
Objective To explore the clinical efficacy of Guizhi Fuling Pill combined with dinorecept in the treatment of endometriosis and its improvement on endometrial receptivity in patients.Methods According to treatment method,138 patients with endometriosis who visited the First Affiliated Hospital of Nanyang Medical College from May 2021 to May 2023 were divided into a control group(69 cases)and an observation group(69 cases).Patients in the control group were treated with oral administration of Dinorecept tablets,while the observation group was treated with oral administration of Guizhi Fuling Pills on the basis of the above.Compare the clinical efficacy of two groups,including hormone levels in the body,endometrial receptivity,and serum levels of carbohydrate antigen 125(CA125),vascular endothelial cell growth factor(VEGF),mitogen-activated protein kinase(MAPK)before and after treatment.Results The clinical efficacy of the observation group was more significant than that of the control group(P<0.05).After treatment,the levels of luteinizing hormone,estradiol,and follicle stimulating hormone in both groups decreased,and the observed group showed a greater decrease compared to the control group(P<0.05).Both groups showed an increase in endometrial volume after treatment,and the observed group showed a greater increase compared to the control group;Both groups showed an increase in endometrial thickness,and the observed group showed a greater increase compared to the control group;Both groups showed a decrease in blood flow resistance index and pulsatility index,and the observed group showed a greater decrease compared to the control group(P<0.05).After treatment,the levels of serum CA125,VEGF,and MAPK in both groups decreased,and the observed group showed a greater decrease compared to the control group(P<0.05).Conclusion The combination of Guizhi Fuling Pill and Dinorecept has a definite therapeutic effect on endometriosis,which can effectively regulate the hormone levels in the patient′s body,enhance endometrial receptivity,and regulate serum levels of CA125,VEGF,and MAPK.
作者
陈亚敏
冯成参
Chen Yamin;Feng Chengcan(Second Ward of Gynecology,First Affiliated Hospital of Nanyang Medical College,Nanyang,Henan473000,China)
出处
《中国药物与临床》
CAS
2023年第7期461-465,共5页
Chinese Remedies & Clinics
