摘要
心房颤动(简称房颤)是危害我国中老年人群健康的重要疾病,与脑卒中、死亡风险有关。目前房颤的发生和发展可通过心房结构重构、电重构、炎症、自主神经系统障碍、非编码RNA等病理生理学机制来解释。房颤的治疗方法主要包括抗凝、转复窦性心律、控制心室率。此外,抗炎、自主神经干预、基因组学干预等疗法或可成为房颤的新型治疗方法。本文将对房颤的发病机制和治疗方法的研究进展进行综述。
Atrial fibrillation(AF)has become an important disease that endangers the health of middle-aged and elderly people in China,and it is related to the risk of stroke and death.At present,pathophysiological mechanisms such as atrial structural remodeling,electrical remodeling,inflammation,autonomic nervous system disorders,and non-coding RNA may explain the occurrence and development of AF.The treatment of AF mainly includes anticoagulation,conversion of sinus rhythm,and control of ventricular rate.In addition,anti-inflammatory,autonomic nerve intervention and genomics intervention therapy may become new types of therapies for AF.This article reviews the research progress in the pathogenesis and treatment of AF.
作者
李含
蔡薇
LI Han;CAI Wei(Department of Cardiology,the Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou Jiangsu 215000,China)
出处
《实用心电学杂志》
2024年第1期87-92,共6页
Journal of Practical Electrocardiology
关键词
心房颤动
心房重构
炎症
自主神经系统
非编码RNA
atrial fibrillation
atrial remodeling
inflammation
autonomic nervous system
non-coding RNA
