摘要
维生素D受体在女性生殖器官中广泛表达,维生素D与维生素D受体结合调节体内骨和钙稳态,参与炎症、细胞介导免疫、细胞周期和凋亡等多种信号通路。维生素D对卵泡发育和卵巢储备、子宫内膜容受性有调节作用;维生素D缺乏与多囊卵巢综合征病理进程有关;补充维生素D对预防卵巢早衰、子宫肌瘤、子宫内膜异位症和卵巢癌有重要意义;体内维生素D水平与体外受精结局也有一定相关性。维生素D缺乏是一个主要公共卫生问题,合理补充维生素D,有益于维护女性生殖健康。
Vitamin D receptor(VDR)is widely expressed in female reproductive organs,and vitamin D binds with VDR to regulate bone and calcium homeostasis and participate in various signaling pathways such as inflammation,cell-mediated immunity,cell cycle,and apoptosis inside the body.Vitamin D regulates follicular development,ovarian reserve,and endometrial receptivity,and vitamin D deficiency is associated with the pathological process of polycystic ovary syndrome.Vitamin D supplementation is of great significance in preventing premature ovarian failure,uterine myoma,endometriosis,and ovarian cancer.The level of vitamin D inside the body is also associated with the outcome of in vitro fertilization.Vitamin D deficiency is a major public health problem,and reasonable supple-mentation of vitamin D may help to maintain female reproductive health.
作者
张爱萍
杨霞
张学红
Zhang Aiping;Yang Xia;Zhang Xuehong(The Assisted Reproductive Medicine Center of The First Hospital of Lanzhou University,The First Clinical Medical College of Lanzhou University,Key Laboratory for Reproductive Medicine and Embryo of Gansu Province)
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2024年第1期12-17,共6页
Journal of Chongqing Medical University
基金
国家自然科学基金资助项目(编号:81960273)。
关键词
维生素D
卵巢储备
内膜容受性:多囊卵巢综合征
卵巢早衰
子宫肌瘤
子宫内膜异位症
卵巢癌
体外受精
vitamin D
ovarian reserve
endometrial receptivity
polycystic ovarian syndrome
premature ovarian failure
uterine myoma
endometriosis
ovarian cancer
in vitro fertilization
