摘要
目的探讨临床-生化评价脂溶性抗氧化剂治疗妊娠高血压疾病的有效性。方法选取2021年1月—2022年7月广东省东莞市黄江医院收治的100例妊娠期高血压疾病患者为对象。通过随机抽签法将患者分为2组,每组50例。对照组采用常规综合疗法,观察组联用维生素E治疗。比较2组患者的疾病指标、凝血功能指标、氧化应激指标。结果治疗前,2组患者疾病指标比较,差异无统计学意义(P>0.05);治疗1周后,2组患者舒张压、收缩压、24 h尿蛋白定量均低于治疗前,且观察组舒张压、收缩压、24 h尿蛋白定量分别为(82.11±4.58)mmHg、(131.42±6.42)mmHg、(0.17±0.04)g,低于对照组的(88.79±4.73)mmHg、(139.72±6.74)mmHg、(0.26±0.06)g,差异有统计学意义(P<0.05)。治疗前,2组患者凝血功能指标比较,差异无统计学意义(P>0.05);治疗1周后,2组患者凝血酶原时间(prothrombin time,PT)、凝血酶时间(thrombin time,TT)、活化部分凝血活酶时间(activated partial thromboplastin time,APTT)、纤维蛋白原(fibrinogen,FIB)优于治疗前,且观察组PT、TT、APTT、FIB优于对照组,差异有统计学意义(P<0.05)。治疗前,2组患者氧化应激指标比较,差异无统计学意义(P>0.05);治疗1周后,2组患者丙二醛(malonaldehyde,MDA)、缺血修饰白蛋白(ischemia modified albumin,IMA)、髓过氧化物酶(myeloperoxidase,MPO)均低于治疗前,且观察组MDA、IMA、MPO低于对照组,差异有统计学意义(P<0.05)。结论脂溶性抗氧化剂可在妊娠高血压疾病治疗中发挥较好的效果,通过临床-生化评价可辅助临床及时明确患者的疾病转归情况,有利于临床更好地运用药物治疗疾病。
Objective To explore the clinical and biochemical evaluation of the effectiveness of fat-soluble antioxidants in the treatment of pregnancy-induced hypertensiony.Methods A total of 100 patients with pregnancy-induced hypertension treated in Dongguan Huangjiang Hospital,Guangdong Province from January 2021 to July 2022 were selected as the subjects.The patients were randomly divided into two groups,with 50 cases in each group.The control group was treated with conventional combined therapy,and the observation group was treated with vitamin E.The indexes of disease,coagulation function and oxidative stress were compared between the two groups.Results Before treatment,there was no significant difference in disease indexes between 2 groups(P>0.05).After 1 week of treatment,the diastolic blood pressure,systolic blood pressure and 24 h urinary protein quantity in 2 groups were lower than before treatment,and the diastolic blood pressure,systolic blood pressure and 24 h urinary protein quantity in observation group were(82.11±4.58)mmHg,(131.42±6.42)mmHg and(0.17±0.04)g,respectively.Lower than control group(88.79±4.73)mmHg,(139.72±6.74)mmHg,(0.26±0.06)g,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in coagulation function indexes between 2 groups(P>0.05).After 1 week of treatment,prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT)and fibrinogen(FIB)were better than those before treatment,and PT,TT,APTT and FIB in observation group were better than those in control group,the difference was statistically significant(P<0.05).Before treatment,there was no statistical significance in oxidative stress index between 2 groups(P>0.05).After 1 week of treatment,malonaldehyde(MDA),ischemia modified albumin(IMA)and myeloperoxidase(MPO)in 2 groups were lower than before treatment.MDA,IMA and MPO in observation group were lower than those in control group,the difference was statistically significant(P<0.05).Conclusion Fat-soluble antioxidants can play a good effect in the treatment of pregnancy hypertension diseases,and clinicalbiochemical evaluation can assist clinical timely clarification of the disease outcome of patients,which is conducive to better clinical use of drugs to treat diseases.
作者
周茜
罗广华
李开梅
徐金花
叶珊羽
吴维
ZHOU Qian;LUO Guanghua;LI Kaimei;XU Jinhua;YE Shanyu;WU Wei(Department of Obstetrics and Gynecology,Dongguan Huangjiang Hospital,Guangdong Province,Dongguan Guangdong 523750,China)
出处
《中国卫生标准管理》
2024年第2期149-152,共4页
China Health Standard Management
基金
东莞市社会发展科技项目(20211800900812)。
关键词
妊娠高血压疾病
脂溶性抗氧化剂
维生素E
疾病指标
凝血功能
氧化应激
pregnancy-induced hypertension
fat-soluble antioxidants
vitamin E
disease indicators
coagulation function
oxidative stress
