摘要
目的分析四川地区藏族健康人群糖化血红蛋白(HbA1c)水平,初步建立四川地区藏族健康人群HbA1c的参考区间。方法选取该院2020年1月至2022年12月藏族健康者2380例作为研究对象,按照年龄分为≤30岁组、>30~40岁组、>40~50岁组、>50~60岁组、>60~70岁组、>70岁组,采用离子交换高效液相色谱法检测HbA1c水平,并对数据进行正态性检验,分析比较不同性别及各年龄组HbA1c水平的差异。采用Pearson相关分析评估HbA1c水平与年龄的相关性。采用间接法建立HbA1c参考区间,并验证获得参考区间。结果四川地区男、女性藏族健康人群HbA1c水平比较,差异无统计学意义(P>0.05);HbA1c水平与年龄呈正相关(r=0.226,P<0.05);≤30岁、>30~40岁、>40~50岁及>50岁藏族健康人群HbA1c参考区间分别为4.73%~6.57%、4.91%~6.75%、4.94%~7.02%和5.02%~7.20%。结论四川地区藏族健康人群HbA1c水平与年龄有关,与性别无关;各地区有必要建立适宜的参考区间,为区域内糖尿病的筛选、诊断及管理提供参考依据。
Objective To analyze the level of glycated hemoglobin(HbA1c)in healthy Tibetan population in Sichuan province,and establish the reference interval of HbA1c in healthy Tibetan population in Sichuan province.Methods A total of 2380 healthy Tibetan people in the hospital from January 2020 to December 2022 were selected as the research objects.The patients were divided into≤30 years old group,>30-40 years old group,>40-50 years old group,>50-60 years old group,>60-70 years old group,and>70 years old group according to age.The HbA1c level was detected by ion exchange high performance liquid chromatography,and the data were tested for normality.Pearson correlation analysis was used to evaluate the correlation between HbA1c level and age.Indirect method was used to establish and validate the HbA1c reference intervals.Results There was no significant difference in HbA1c levels between male and female Tibetan healthy people in Sichuan province(P>0.05).HbA1c level was positively correlated with age in Tibetan healthy population(r=0.226,P<0.05).The reference intervals of HbA1c were 4.73%-6.57%,4.91%-6.75%,4.94%-7.02%and 5.02%-7.20%in≤30 years old,>30-40 years old,>40-50 years old and>50 years old,respectively.Conclusion The level of HbA1c in healthy Tibetan population in Sichuan province is related to age,but not to gender.It is necessary to establish appropriate reference intervals for the screening,diagnosis and management of diabetes in each region.
作者
廖清智
刘萍
姜灵路
苟甜甜
LIAO Qingzhi;LIU Ping;JIANG Linglu;GOU Tiantian(Department of Clinical Laboratory,363 Hospital,Chengdu,Sichuan 610041,China)
出处
《检验医学与临床》
2024年第3期402-404,共3页
Laboratory Medicine and Clinic
关键词
藏族表观健康人群
糖化血红蛋白
参考区间
性别
年龄
apparent healthy tibetan population
glycated hemoglobin
reference interval
gender
age
