摘要
目的探讨重组人干扰素α2b凝胶联合子宫颈电热圈环切术(LEEP)刀(超高频电波刀)宫颈锥切术对宫颈上皮内瘤样病变(CIN)合并人乳头瘤病毒(HPV)感染患者免疫功能及炎症指标的影响。方法以随机数字表法将2020年1月至2022年1月收治的86例CIN合并HPV感染患者分为对照组和观察组,各43例。对照组采用LEEP刀宫颈锥切术治疗,观察组在对照组基础上联合重组人干扰素α2b凝胶治疗。比较两组的治疗效果。结果观察组的治疗总有效率为97.67%,高于对照组的83.72%(P<0.05)。观察组的阴道微生物恢复率、HPV转阴率均高于对照组,CIN复发率低于对照组(P<0.05)。治疗后,观察组的免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、免疫球蛋白A(IgA)、白细胞介素-12(IL-12)及干扰素-γ(IFN-γ)水平高于对照组,白细胞介素-10(IL-10)水平低于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论重组人干扰素α2b凝胶联合LEEP刀宫颈锥切术治疗CIN合并HPV感染患者的疗效显著。
Objective To investigate the effects of recombinant human interferonα2b gel combined with loop electrocautery excision procedure(LEEP)knife(ultra-high frequency electric wave knife)cervical conization on immune function and inflammatory indexes in patients with cervical intraepithelial neoplasia(CIN)complicated with human papillomavirus(HPV)infection.Methods A total of 86 patients with CIN complicated with HPV infection admitted from January 2020 to January 2022 were divided into control group and observation group by random number table method,with 43 cases in each group.The control group was treated with LEEP knife cervical conization,and the observation group was treated with recombinant human interferonα2b gel on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was 97.67%,which was higher than 83.72%in the control group(P<0.05).The vaginal microbial recovery rate and HPV negative conversion rate in the observation group were higher than those in the control group,and the CIN recurrence rate was lower than that in the control group(P<0.05).After treatment,the levels of immunoglobulin G(IgG),immunoglobulin M(IgM),immunoglobulin A(IgA),interleukin-12(IL-12)and interferon-γ(IFN-γ)in the observation group were higher than those in the control group,and the level of interleukin-10(IL-10)was lower than that in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Recombinant human interferonα2b gel combined with LEEP knife cervical conization is effective in the treatment of CIN complicated with HPV infection patients.
作者
付青
薛鸿涛
任敏
FU Qing;XUE Hongtao;REN Min(Gynecology Department,Xi'an Maternity and Child Health Care Hospital,Xi'an 710002;Laboratory Department,Hanzhong Hospital of TCM,Hanzhong 723102;Laboratory Department,Mianxian Hospital,Hanzhong 724200,China)
出处
《临床医学研究与实践》
2024年第4期110-113,共4页
Clinical Research and Practice
关键词
宫颈上皮内瘤样病变
人乳头瘤病毒
超高频电波刀
宫颈锥切术
重组人干扰素α2b凝胶
免疫功能
炎症指标
cervical intraepithelial neoplasia
human papillomavirus
ultra-high frequency electric wave knife
cervical conization
recombinant human interferonα2b gel
immune function
inflammatory index
