摘要
运动应激性胃溃疡是运动引起的应激性溃疡(stress ulcer,SU),是一种以黏膜糜烂、溃疡及出血为特征的急性胃黏膜病变,临床调查显示,应激性溃疡除了会导致胃肠道黏膜的急性糜烂、溃疡,通常还会伴随胃肠道出血增多,发展至后期预后不良。自胃溃疡被发现并命名以来,研究人员一直在探讨溃疡的发生机制,由于运动应激性胃溃疡的发病范围广、频率高,其发生机制复杂,本文主要从运动引起的氧化应激产生过多的自由基会损伤胃肠黏膜细胞损坏黏膜的屏障功能、运动系统损伤会加重机体的炎症反应、运动时胃肠道血流量减少易出现缺血损伤、过度运动影响细胞代谢能量供给4个方面对运动应激性胃溃疡发生的机制进行分析总结,旨在为运动应激性胃溃疡的防治提供更多的借鉴与参考。
Exercise stress ulcer is a type of stress ulcer induced by exercise,manifesting as an acute gastric mucosal lesion with mucosal erosion,ulceration and bleeding.Clinical investigations have shown that besides acute erosion and ulceration of gastrointestinal mucosa,stress ulcer is usually accompanied by increased gastrointestinal bleeding,leading to poor prognosis in the later stage.Since gastric ulcer was discovered and named,researchers have explored its pathogenesis.Due to the wide range,high frequency and complex pathogenesis of exercise-induced stress ulcer,this paper mainly analyzed and summarized the mechanism of exercise-induced stress ulcer from four aspects as follows.First of all,oxidative stress caused by exercise produce excessive free radicals to damage gastrointestinal mucosal cells and damage mucosal barrier function.Secondly,injury of exercise system will aggravate the inflammatory response of the body.Thirdly,reduced gastrointestinal blood flow during exercise is prone to ischemic injury.Fourth,excessive exercise affects the metabolic energy supply of cells.This article aims to provide more references for the prevention and treatment of exercise-induced gastric ulcer.
作者
林纯
杨雅琴
刘卫海
卢素宏
LIN Chun;YANG Ya-qin;LIU Wei-hai;LU Su-hong
出处
《中国疗养医学》
2024年第3期45-49,共5页
Chinese Journal of Convalescent Medicine
基金
广东省教育厅青年创新人才项目(2021KQNCX185)
广东食品药品职业学院自然科学项目(2021 ZR10)。
关键词
运动应激
胃溃疡
机制探讨
Exercise stress
Gastric ulcer
Mechanism discussion
