摘要
代谢重编程和表观遗传修饰是肿瘤的重要特征。在肿瘤发生发展过程中,肿瘤细胞改变其新陈代谢途径,表现出可调控的代谢可塑性。肿瘤代谢的改变在很大程度上受到表观遗传修饰的调控,比如,表观遗传修饰酶的表达或活性改变可能对肿瘤代谢产生直接或间接的影响。因此,探讨表观遗传修饰在肿瘤代谢重编程过程中的调控作用,对于深入理解肿瘤的致病机制具有重要意义。本文主要探讨了表观遗传修饰调控肿瘤代谢重编程的最新研究发现,包括DNA甲基化、组蛋白修饰、染色质重塑和非编码RNA对肿瘤代谢重编程的调控,并展望了基于表观遗传修饰调控的肿瘤代谢重编程的治疗前景。
Metabolic reprogramming and epigenetic modifications are important features of cancers.Cancer cells alter their metabolic pathways during tumorigenesis and progression,exhibiting modifiable metabolic plasticity.Alterations in tumor metabolism are largely regulated by epigenetic modifications,e.g.,alterations in the expression or activity of epigenet-ically modified enzymes can have direct and indirect effects on tumor metabolism.Therefore,it is of great significance to explore the regulatory role of epigenetic modifications in tumor metabolic reprogramming,to further understand the patho-genic mechanism of tumors.In this review,we focus on the latest findings of epigenetic modifications regulating tumor meta-bolic reprogramming,including the regulation of tumor metabolic reprogramming by DNA methylation,histone modifica-tion,chromatin remodeling,and non-coding RNAs,and look forward to the therapeutic prospects of tumor metabolic repro-gramming based on the regulation of epigenetic modifications.
作者
许雪萌
崔适文
张文龙
李世臻
欧阳琳达
蒋贤杰
廖前进
彭球
周钰娟
XU Xuemeng;CUI Shiwen;ZHANG Wenlong;LI Shizhen;OUYANG Linda;JIANG Xianjie;LIAO Qianjin;PENG Qiu;ZHOU Yujuan(Graduate Collaborative Training Base of Hunan Cancer Hospital,Hengyang Medical School,University of South China,Hengyang,421001,Hunan,China;Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha,410013,Hunan,China)
出处
《肿瘤药学》
2023年第6期686-692,共7页
Anti-Tumor Pharmacy
基金
国家自然科学基金(82203233、82202966、82173142、81972636、81872281)
湖南省自然科学基金(2022JJ80078、2021JJ70098、2020JJ5336)
湖南省卫生健康委员会项目(202302067467、202203034978、202203231032、202109031837、20201020)
长沙市科技局项目(kh2201054、kq2004136)
湖南省肿瘤医院攀登基金(ZX2020001-3、YF2020002)。
关键词
代谢重编程
表观遗传
DNA甲基化
组蛋白修饰
染色质重塑
Metabolic reprogramming
Epigenetic
DNA methylation
Histone modification
Chromatin remodeling
