摘要
目的:观察参芪固本颗粒治疗支气管哮喘恢复期肺脾气虚证患儿的效果。方法:选取2021年7月至2022年7月平顶山市中医医院收治的90例支气管哮喘恢复期肺脾气虚证患儿进行前瞻性研究,按随机数字表法将其分为研究组和对照组各45例。对照组采用布地奈德吸入气雾剂治疗,研究组在对照组基础上采用参芪固本颗粒治疗。比较两组临床疗效、治疗前后中医证候积分、肺功能指标[第1秒用力呼气容积(FEV_(1))、呼气流量峰值(PEF)]水平、免疫球蛋白指标[免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)]水平、炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-4(IL-4)]水平和不良反应发生率。结果:研究组治疗总有效率为93.33%(42/45),高于对照组的73.33%(33/45),差异有统计学意义(P<0.05);治疗后,两组气喘、咳嗽、喘鸣、咳痰清稀、神疲乏力等中医证候积分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组FEV_(1)、PEF水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组IgA、IgG、IgM水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组TNF-α、IL-6、IL-4水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在布地奈德吸入气雾剂治疗基础上采用参芪固本颗粒治疗支气管哮喘恢复期肺脾气虚证患儿可提高治疗总有效率、肺功能指标和免疫球蛋白指标水平,降低中医证候积分和炎性因子水平,其效果优于单纯布地奈德吸入气雾剂治疗。
Objective:To observe effects of Shenqi Guben granules in treatment of children with lung-spleen qi deficiency syndrome in the recovery period of bronchial asthma.Methods:A prospective study was conducted on 90 children with lung-spleen qi deficiency syndrome in the recovery period of bronchial asthma admitted to Pingdingshan Hospital of Traditional Chinese Medicine from July 2021 to July 2022.They were divided into study group and control group according to the random number table method,45 cases in each group.The control group was treated with Budesonide inhalation aerosol,while the study group was treated with Shenqi Guben granules on the basis of the control group.The clinical efficacy,the TCM syndrome scores before and after the treatment,the lung function indexes[forced expiratory volume in one second(FEV_(1)),peak expiratory flow(PEF)]levels,the immunoglobulin indexes[immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)]levels,the inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-4(IL-4)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 93.33%(42/45),which was higher than 73.33%(33/45)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as asthma,cough,wheezing,expectoration,and fatigue in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of FEV_(1) and PEF in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of IgA,IgG and IgM in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of TNF-α,IL-6 and IL-4 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:On the basis of Budesonide inhalation aerosol treatment,Shenqi Guben granules can improve the total effective rate,the lung function index and immunoglobulin index levels,and reduce the TCM syndrome scores and the inflammatory factor levels in the treatment of the children with lung-spleen qi deficiency syndrome in the recovery period of bronchial asthma.Moreover,it is superior to single Budesonide inhalation aerosol treatment.
作者
陈万越
李宁
任大鹏
李君
CHEN Wanyue;LI Ning;REN Dapeng;LI Jun(Pediatrics Department of Pingdingshan Hospital of Traditional Chinese Medicine,Pingdingshan 467000 Henan,China;School of Pediatrics Henan University of Traditional Chinese Medicine,Zhengzhou 450000 Henan,China)
出处
《中国民康医学》
2024年第2期102-105,共4页
Medical Journal of Chinese People’s Health
基金
2022年河南省中医药科学研究专项课题(2022ZY2067)。
关键词
参芪固本颗粒
布地奈德吸入气雾剂
支气管哮喘
恢复期
肺脾气虚证
肺功能
Shenqi Guben granules
Budesonide inhalation aerosol
Bronchial asthma
Recovery period
Lung-spleen qi deficiency syndrome
Lung function
