摘要
炎症性肠病(IBD)分为溃疡性结肠炎和克罗恩病,是一种与免疫功能紊乱密切相关的慢性复发性炎症性胃肠道疾病。IBD的发病机制与遗传易感性、免疫功能障碍、环境改变和肠道微生物群紊乱密切相关。现代研究发现,巨噬细胞极化在IBD发生发展中占有重要地位,能够影响炎症反应水平、肠道黏膜修复及肠道微生物群平衡等,是治疗IBD的潜在靶点。越来越多的研究表明,中药及其有效成分能够通过多途径调节巨噬细胞极化,平衡M1/M2巨噬细胞比率,从而抑制炎症反应,促进肠黏膜修复,减缓IBD的进一步发展。该文通过总结巨噬细胞极化的生物学过程与涉及靶点,详述其在IBD中的影响。同时对中药及其有效成分能够通过调控巨噬细胞极化改善IBD的最新研究作简要综述,以期为中医药治疗IBD更好应用于临床提供新方向与新策略。
Inflammatory bowel disease(IBD),consisting of ulcerative colitis and Crohn's disease,is a chronic relapsing inflammatory gastrointestinal disease closely associated with immune dysfunction.The pathogenesis of IBD is closely related to genetic susceptibility,immune system dysfunction,environmental change,and intestinal microbial dysbiosis.Modern research has found that macrophage polarization plays an important role in the development of IBD and can affect the level of inflammatory response,intestinal mucosal repair,and intestinal microbial balance,making it a potential target for IBD treatment.Increasing evidence suggests that traditional Chinese medicine and its active components can regulate macrophage polarization through multiple pathways and balance the M1/M2 macrophage ratio,thus inhibiting inflammatory response,promoting intestinal mucosal repair,and slowing down the progression of IBD.This article summarized the biological processes and targets involved in macrophage polarization and discussed its impact on IBD.It also provided a brief overview of the latest research on how traditional Chinese medicine and its active components can improve IBD by regulating macrophage polarization,so as to provide new directions and strategies for the clinical application of traditional Chinese medicine in IBD treatment.
作者
刘艺
刘源
孙志其
鲁明源
LIU Yi;LIU Yuan;SUN Zhiqi;LU Mingyuan(Shandong University of Traditional Chinese Medicine(TCM),Jinan 250300,China;The First Clinical Medical School of Shandong University of TCM,Jinan 250300,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2024年第2期276-286,共11页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家中医药管理局高水平中医药重点学科建设项目(zyyzdxk-2023118)
山东中医药大学中医药经典理论教育部重点实验室项目。
关键词
中药
有效成分
巨噬细胞极化
炎症性肠病
研究进展
traditional Chinese medicine
active components
macrophage polarization
inflammatory bowel disease
research progress
