摘要
目的探讨感冒清热片防治甲型H1N1流感病毒感染的药效学情况。方法108例甲型H1N1流感病毒感染患者,随机分为观察组和对照组,每组54例。对照组使用磷酸奥司他韦治疗,观察组在对照组治疗基础上使用感冒清热片治疗。比较两组患者临床疗效、症状改善指标(起效时间、退热时间、止咳时间、痊愈时间)、以及治疗前后的中医证候(发热、咽痛、头痛、鼻塞流涕、咳嗽、乏力)积分、血清炎性因子[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]。结果观察组治疗总有效率96.30%高于对照组的77.78%(P<0.05)。治疗后,观察组患者发热、咽痛、头痛、鼻塞流涕、咳嗽、乏力评分分别为(0.83±0.24)、(1.12±0.30)、(1.07±0.29)、(1.03±0.32)、(1.05±0.33)、(1.09±0.28)分,均低于对照组的(1.46±0.37)、(2.31±0.58)、(2.14±0.52)、(2.25±0.63)、(2.36±0.61)、(2.42±0.65)分(P<0.05)。观察组起效时间(1.03±0.34)d、退热时间(1.56±0.40)d、止咳时间(4.35±0.68)d、痊愈时间(6.63±1.26)d均短于对照组的(2.32±0.57)、(2.63±0.74)、(7.24±1.16)、(9.38±1.72)d(P<0.05)。治疗后,观察组CRP(2.11±0.56)mg/L、TNF-α(19.34±2.20)μg/L、IL-6(4.02±0.54)ng/L均低于对照组的(4.83±0.69)mg/L、(25.89±2.73)μg/L、(6.13±0.62)ng/L(P<0.05)。结论感冒清热片防治甲型H1N1流感病毒感染的疗效显著,能有效缓解证候,加快症状缓解速度,提高抗炎作用。
Objective To investigate the pharmacodynamics of Ganmao Qingre tablets in the prevention and treatment of H1N1 influenza A virus infection.Methods A total of 108 patients with H1N1 influenza A virus infection were randomly divided into an observation group and a control group.The control group was treated with oseltamivir phosphate,and on the basis of this,the observation group was treated with Ganmao Qingre tablets.The clinical efficacy,symptom improvement indicators(onset time,antipyretic time,cough relieving time,recovery time),traditional Chinese medicine syndrome(fever,sore throat,headache,nasal congestion and nasal discharge,cough,fatigue)score,and serum inflammatory factors[C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]of the two groups were compared.Results The treatment effective rate of 96.30%in the observation group was significantly higher than 77.78%in the control group(P<0.05).After treatment,the scores of fever,sore throat,headache,nasal congestion and nasal discharge,cough,and fatigue in the observation group were(0.83±0.24),(1.12±0.30),(1.07±0.29),(1.03±0.32),(1.05±0.33),and(1.09±0.28)points,which were significantly lower than(1.46±0.37).(2.31±0.58),(2.14±0.52),(2.25±0.63),(2.36±0.61),and(2.42±0.65)points in the control group(P<0.05).The onset time,antipyretic time,cough relieving time and recovery time in the observation group were(1.03±0.34),(1.56±0.40),(4.35±0.68)and(6.63±1.26)d,which were shorter than(2.32±0.57),(2.63±0.74),(7.24±1.16)and(9.38±1.72)d in the control group(P<0.05).After treatment,the levels of CRP of(2.11±0.56)mg/L,TNF-αof(19.34±2.20)μg/L and IL-6 of(4.02±0.54)ng/L in the observation group were lower than(4.83±0.69)mg/L,(25.89±2.73)μg/L and(6.13±0.62)ng/L in the control group(P<0.05).Conclusion Ganmao Qingre Tablets has significant effect on the prevention and treatment of influenza A virus infection,in that it can effectively alleviate the syndromes,speed up the relief of symptoms and improve the anti-inflammatory effect.
作者
钟文
王小刚
ZHONG Wen;WANG Xiao-gang(General Department,Chengdu Third People's Hospital,Chengdu 610000,China)
出处
《中国现代药物应用》
2024年第2期110-113,共4页
Chinese Journal of Modern Drug Application
