摘要
目的:研究化痰止咳平喘汤联合布地奈德治疗慢性阻塞性肺疾病急性加重期(COPD)的效果及作用机制。方法:选取急性加重期COPD患者94例,采用随机数字表法分为观察组及对照组各47例。对照组患者接受布地奈德联合常规方案治疗;观察组患者在上述治疗方案的基础上联合化痰止咳平喘汤治疗;记录并比较两组患者治疗有效率、治疗前后主要临床症状(咳嗽咳痰、气促气短、胸闷胀痛)的中医症候积分、用力肺活量(FVC)、呼气峰流量(PEF)、第一秒用力呼气容积占FVC百分比(FEV_(1)/FVC)、二氧化碳分压(PaCO_(2))、血氧气分压(PaO_(2))、6 min步行试验距离(6MWT)以及不良反应发生率。结果:观察组治疗有效率为95.74%,显著高于对照组的82.98%(P<0.05);治疗后,两组咳嗽咳痰、气促气短、胸闷胀痛的中医症候积分相比治疗前均下降,且观察组低于对照组(P<0.05);两组FVC、PEF、FEV_(1)/FVC、PaO_(2)评分及6MWT相较治疗前均出现上升,PaCO_(2)相比治疗前下降,且观察组变化更加显著(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:化痰止咳平喘汤联合布地奈德可有效改善COPD患者临床症状、促进肺功能的改善且未增加患者的不良反应发生率。
Objective:To study the effect and action mechanism of Huatan Zhike Pingchuan decoction combined with budesonide in the treatment of acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods:A total of 94 patients with acute exacerbation of COPD were enrolled.According to random number table method,they were divided into observation group(n=47) and control group(n=47).The control group was given budesonide combined with routine regimen,while observation group was additionally treated with Huatan Zhike Pingchuan decoction.The response rate of treatment,scores of main TCM syndromes(cough and expectoration,shortness of breath,chest swelling and pain),forced vital capacity(FVC),peak expiratory flow(PEF),forced expiratory volume in 1 second/FVC(FEV_(1)/FVC),partial pressure of carbon dioxide(PaCO_2),partial pressure of blood oxygen(PaO_(2)),6 minute walking distance(6MWT) and incidence of adverse reactions in the two groups were compared before and after treatment.Results:The response rate of treatment in observation group was significantly higher than that in control group(P<0.05).After treatment,scores of main TCM syndromes in both groups were decreased,which were lower in observation group than control group(P<0.05).After treatment,FVC,PEF,FEV_(1)/FVC,PaO_(2) and 6MWT were increased,while PaCO_(2) was decreased in both groups,and the above changes were more significant in observation group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Huatan Zhike Pingchuan decoction combined with budesonide can effectively improve clinical symptoms and promote the improvement of pulmonary function in COPD patients,with low incidence of adverse reactions.
作者
刘敬敬
程玉峰
崔磊
LIU Jingjing;CHENG Yufeng;CUI Lei(Bozhou Hospital of Traditional Chinese Medicine,Bozhou 236800,China)
出处
《陕西中医》
CAS
2024年第2期204-207,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
国家中医药管理局中医药循证能力建设项目(2019XZZX-LG001)。
关键词
慢性阻塞性肺疾病
急性加重期
布地奈德
化痰止咳平喘汤
呼吸功能
血气分析
Chronic obstructive pulmonary disease
Acute exacerbation
Budesonide
Huatan Zhike Pingchuan decoction
Respiratory function
Blood gas analysis
