摘要
目的 观察宣白承气汤对慢性阻塞性肺疾病急性加重期(AECOPD)(痰热壅肺证)的临床疗效、肠道微生态、炎症指标及二氧化碳分压(PaCO_(2))的影响。方法 将80例AECOPD(痰热壅肺证)患者随机分为两组,对照组实施西医的常规治疗,观察组则另外加上宣白承气汤治疗,疗程均为7 d,观察并记录两组患者治疗前后中医证候积分、肠道微生物菌种丰度、C反应蛋白(CRP)、降钙素原(PCT)、中性粒细胞百分比(N%)及PaCO_(2)的变化。结果 观察组临床疗效显著优于对照组(P<0.05)。治疗后,观察组咳嗽、喘息等中医证候积分显著低于对照组(P<0.05),两组患者乳杆菌、拟杆菌、双歧杆菌以及肠杆菌丰度均升高(P<0.05),且与对照组比较,观察组患者乳杆菌、拟杆菌、双歧杆菌以及肠杆菌丰度明显升高(P<0.05)。两组PaCO_(2)、CRP、PCT、N%较治疗前均降低(P<0.05),且低于同期对照组(P<0.05)。结论 宣白承气汤可改善AECOPD(痰热壅肺证)患者的临床症状及肠道微生态,可一定程度改善患者二氧化碳潴留,并有效降低患者CRP、PCT、N%比水平。
Objective:To analysis the effect of Xuanbai Chengqi Decoction on the clinical efficacy,gut microbiota,inflammatory parameters and partial pressure of carbon dioxide(PaCO_(2))in acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with phlegm-heat obstructing the lung.Methods:A total of 80 patients with AECOPD with phlegm-heat obstructing lung type were randomly divided into two groups.The control group was given routine western medicine treatment.The experimental group also received Xuanbai Chengqi Decoction on the basis of routine western medicine treatment.After treatment for 7 days,the traditional Chinese medicine(TCM)symptom scores,gut microbiota abundance,C-reactive protein(CRP),procalcitonin(PCT),neutrophil percentage(N%)and changes in PaCO_(2) were recorded.Results:The clinical efficacy of the experimental group was significantly better than that of the control group(P<0.05).After treatment,the TCM symptom score of cough and wheezing in the experimental group were significantly lower than that of the control group(P<0.05).The abundances of lactobacillus,bacteroides,bifidobacterium and enterobacteriaceae were increased in both groups,and the increases in the experimental group were more prominent than those in the control group(P<0.05).The PaCO_(2),CRP,PCT and N%were all significantly decreased compared with before treatment(P<0.05),and the decreases in the experimental group were more significant(P<0.05).Conclusion:Xuanbai Chengqi Decoction can improve the clinical symptoms and gut microbiota of patients with AECOPD with phlegm-heat obstructing the lung type,decrease carbon dioxide retention to a certain extent,and effectively reduce the CRP,PCT and N%levels.
作者
徐倍琪
黄辉
陈晖
王寒松
姜斌贤
毕闻远
Lung Type Xu Beiqi;Huang Hui;Chen Hui;Wang Hansong;Jiang Binxian;Bi Wenyuan(Kunshan Hospital of Traditional Chinese Medicine,Jiangsu,Kunshan 215300,China)
出处
《中国中医急症》
2024年第1期123-126,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
江苏省自然科学基金(BK20200260)
昆山市级科技专项(KJJKJZXSF2020024)。
关键词
慢性阻塞性肺疾病
宣白承气汤
肺肠同治
痰热壅肺型
肠道微生态
Chronic obstructive pulmonary disease
Xuanbai Chengqi Decoction
Simultaneous treatment of lung and intestine
Phlegm-heat obstructing lung type
Gut microbiota
