摘要
目的研究非ST段抬高心肌梗死患者基利普分级(Killip)与血清微小RNA33(microRNA-33,miR-33)、微小R NA-122(microR NA-122,miR-122)水平及心电图QRS波时限的关系,为非ST段抬高心肌梗死疾病评估提供理论基础。方法本研究为前瞻性病例对照研究,选取南充市中心医院2018年10月—2021年1月治疗的心肌梗死患者96例为观察组,根据Killip分级等级分为Ⅰ级(21例)、Ⅱ级(42例)、Ⅲ级(19例)和Ⅳ级(14例)。选取同期在该院体检健康的成年人80名为对照组。对比全部受试者血清miR-33、miR-122水平和心电图QRS波时限。采用Pea rson相关分析冠心病患者血清miR-33、miR-122水平及心电图QRS波时限与Killip分级的关系。结果不同Killip等级患者血清miR-33、miR-122水平及心电图QRS波时限对比,差异有统计学意义(F=72.16、56.81、23.40,P均<0.001);其中KillipⅣ级患者的miR-33、miR-122水平和心电图QRS波时限高于对照组Ⅰ级、Ⅱ级、Ⅲ级,KillipⅢ级患者的miR-33、miR-122水平和心电图QRS波时限高于对照组Ⅰ级、Ⅱ级,KillipⅡ级患者的miR-33、miR-122水平和心电图QRS波时限高于对照组Ⅰ级,差异具有统计学意义(t=2.15~13.77,P均<0.05)。经Pea rson相关分析得出,患者血清miR-33、miR-122水平及心电图的QRS波时限均与Killip分级呈正相关(r=0.411、0.398、0.428,P均<0.001)。结论非ST段抬高心肌梗死患者血清miR-33、miR-122水平、心电图QRS波时限和Killip分级呈正相关,可为非ST段抬高心肌梗死患者的病情评估提供一定的临床参考价值。
Objective To study the relationships between Killip grading and serum levels of minimal microRNA-33(miR-33)and minimal microRNA-122(miR-122)as well as the QRS durations of electrocardiograms in patients with non ST segment elevation myocardial infarction so as to provide data for assessment of related diseases.Methods In this prospective case-control study,96 patients with myocardial infarction treated in Nanchong Central Hospital between October 2018 and January 2021 were selected as the observation group,who were divided into gradeⅠgroup(n=21),gradeⅡgroup(n=42),gradeⅢgroup(n=19),and gradeⅣgroup(n=14)based on Killip grading.Another 80 healthy adults who underwent physical examination in our hospital were selected as the control group.The serum levels of miR-33 and miR-122 and durations of QRS wave on electrocardiograms were compared between the two groups.Pearson correlation analysis was used to investigate the relationships between serum miR-33 and miR-122 levels,electrocardiogram QRS wave durations,and Killip grading in patients with coronary heart disease.Results There were statistically significant differences in serum levels of miR-33 and miR-122 and in QRS durations of ECGs between the control group and the observation group(F=72.16,56.81,23.40,all P<0.001).The serum levels of miR-33 and miR-122 and the QRS durations of ECGs in KillipⅣpatients were higher than those of the control group and those of patients of gradeⅠ,ⅡandⅢ,and were higher in KillipⅢpatients than in the control group and in patients of gradeⅠandⅡ.These indexes were higher in KillipⅡpatients than in the control group and in patients of gradeⅠ,and higher in KillipⅠpatients than in the control group.The differences were statistically significant(t=2.15-58.14,P<0.05).Pearson correlation analysis showed that the serum levels of miR-33 and miR-122 and QRS wave durations of ECGs were positively correlated with Killip grading(r=0.411,0.398,0.428,all P<0.001).Conclusion There is a positive correlation between serum miR-33,miR-122 levels,electrocardiogram QRS wave durations,and Killip grading in patients with coronary heart disease,which can provide reference for the assessment of conditions of non ST segment elevation myocardial infarction patients.
作者
范红芬
范思槟
张琳
FAN Hongfen;FAN Sibin;ZHANG Lin(Department of Cardiology,Nanchong Central Hospital,Nanchong 637000;Disease Prevention and Control Center of Gaoping District,Nanchong 637006,China)
出处
《空军航空医学》
2023年第6期508-513,共6页
AVIATION MEDICINE OF AIR FORCE
基金
四川省基层卫生事业发展研究中心项目(SWFZ16-Y-32)。
