摘要
为了提高雷美替胺药品的质量,结合已报道的合成工艺路线,针对其关键的还原工序,设计并定向合成了3种雷美替胺的杂质Imp1、Imp2和Imp3,所有杂质均通过^(1)HNMR、^(13)CNMR和MS确证了结构。所合成的杂质可作为对照品,为雷美替胺合成工艺优化、分析方法开发和质量研究提供一定的帮助。
In order to improve the quality of ramelteon drug,three impurities Imp1,Imp2and Imp3of ramelteon were designed and synthesized according to the reported synthesis process and the key reduction process.The chemical structures of the impurities were confirmed by ^(1)HNMR,^(13)CNMR and MS.These impurities can be used as reference materials to promote the synthesis process optimization,analytical method development and quality research of ramelteon drug.
作者
潘学春
陆冬冬
梁震林
武华周
吴晶
柴雨柱
徐丹
朱春霞
PAN Xue-chun;LU Dong-dong;LIANG Zhen-lin;WU Hua-zhou;WU Jing;CHAI Yu-zhu;XU Dan;ZHU Chun-xia(Nanjing Chia-Tai Tianqing Pharmaceutical Co.,Ltd.,Nanjing 210046,China)
出处
《精细与专用化学品》
CAS
2024年第1期17-20,共4页
Fine and Specialty Chemicals
关键词
褪黑素受体
雷美替胺
杂质
合成
melatonin receptor
ramelteon
impurities
synthesis
