摘要
目的探讨中青年原发性高血压患者血清可溶性信号素4D(sSema4D)、CXC趋化因子配体12(CXCL12)水平与左心室舒张功能的关系。方法选取该院2020年11月至2022年11月收治的148例中青年原发性高血压患者为研究对象,并根据患者左心室舒张功能分为左心室舒张功能不全组41例和左心室舒张功能正常组107例。采用酶联免疫吸附试验检测血清sSema4D、CXCL12水平,Pearson相关性分析血清sSema4D、CXCL12水平与患者左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、舒张末期室间隔厚度(IVST)、左心室舒张末期后壁厚度(LVPWT)、左心室射血分数(LVEF)、E峰/A峰(E/A)和三尖瓣反流最大速度(TRVmax)的相关性。受试者工作特征(ROC)曲线分析血清sSema4D和CXCL12水平对中青年原发性高血压患者左心室舒张功能不全的预测价值。结果左心室舒张功能不全组和左心室舒张功能正常组舒张压和性别比较差异有统计学意义(P<0.05)。与左心室舒张功能正常组比较,左心室舒张功能不全组血清sSema4D、CXCL12水平明显升高,差异有统计学意义(P<0.05)。与左心室舒张功能正常组比较,左心室舒张功能不全组IVST和LVPWT明显升高,E/A明显降低,差异有统计学意义(P<0.05)。Pearson相关性分析显示,血清sSema4D和CXCL12水平均与LVEDD、IVST、LVPWT呈正相关(P<0.05),与E/A呈负相关(P<0.05)。ROC曲线分析显示,血清sSema4D、CXCL12联合预测中青年原发性高血压患者左心室舒张功能不全的曲线下面积(AUC)为0.894(95%CI:0.833~0.939),显著大于sSema4D单独预测中青年原发性高血压患者左心室舒张功能不全的AUC(Z=3.142,P=0.002)和CXCL12单独预测中青年原发性高血压患者左心室舒张功能不全的AUC(Z=3.268,P=0.001)。结论血清sSema4D和CXCL12水平与中青年原发性高血压患者左心室舒张功能有关。
Objective To explore the relationship between serum soluble semaphorin 4D(sSema4D),CXC chemokine ligand 12(CXCL12)levels and left ventricular diastolic function in young and middle-aged patients with essential hypertension.Methods A total of 148 young and middle-aged patients with essential hypertension admitted to a hospital from November 2020 to November 2022 were selected as the study subjects,and were grouped into left ventricular diastolic dysfunction group(n=41)and normal left ventricular diastolic function group(n=107)according to their left ventricular diastolic function.The serum levels of sSema4D and CXCL12 were detected by enzyme-linked immunosorbent assay.Pearson correlation analysis was applied to analyze the correlation between the serum levels of sSema4D and CXCL12 and the left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular septal thickness(IVST),left ventricular end-diastolic posterior wall thickness(LVPWT),left ventricular ejection fraction(LVEF),E peak/A peak(E/A)and maximum velocity of tricuspid regurgitation(TRVmax).The predictive value of serum sSema4D and CXCL12 levels in left ventricular diastolic dysfunction in young and middle-aged patients with essential hypertension was analyzed by receiver operating characteristic(ROC)curve.Results There were significant differences in diastolic blood pressure and gender between the left ventricular diastolic dysfunction group and the left ventricular diastolic function normal group(P<0.05).Compared with the normal left ventricular diastolic function group,serum levels of sSema4D,CXCL12 in the left ventricular diastolic dysfunction group were obviously increased,and the difference was statistically significant(P<0.05).Compared with normal left ventricular diastolic function group,IVST and LVPWT in the left ventricular diastolic dysfunction group were significantly increased,and E/A was significantly decreased,with statistical significance(P<0.05).Pearson correlation analysis showed that serum sSema4D and CXCL12 levels were positively correlated with LVEDD,IVST and LVPWT(P<0.05),and negatively correlated with E/A(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum sSema4D and CXCL12 combined in predicting left ventricular diastolic dysfunction in young and middle-aged patients with essential hypertension was 0.894(95%CI:0.833-0.939),which was significantly greater than that of sSema4D alone in predicting left ventricular diastolic dysfunction in young and middle-aged patients with essential hypertension(Z=3.142,P=0.002)and CXCL12 alone predicted the AUC of left ventricular diastolic dysfunction in young and middle-aged patients with essential hypertension(Z=3.268,P=0.001).Conclusion Serum sSema4D and CXCL12 levels are associated with left ventricular diastolic function in young and middle-aged patients with essential hypertension.
作者
陈珅
朱磊
张梦瑶
李卿
林文静
张玉
张文亮
CHEN Shen;ZHU Lei;ZHANG Mengyao;LI Qing;LIN Wenjing;ZHANG Yu;ZHANG Wenliang(Second Ward,Department of Geriatrics,Shijiazhuang People′s Hospital,Shijiazhuang,Hebei 050000,China;Department of Endocrinology,Shijiazhuang People′s Hospital,Shijiazhuang,Hebei 050000,China)
出处
《国际检验医学杂志》
CAS
2024年第3期261-265,共5页
International Journal of Laboratory Medicine
基金
河北省医学科学研究项目(20210475)。
