摘要
目的:探讨甲氨蝶呤宫腔内注射联合宫腔镜下清宫术治疗子宫瘢痕妊娠(cesarean scar pregnancy,CSP)的临床效果。方法:选择2021年1月—2022年12月北京市第一中西医结合医院接诊的72例CSP患者作为研究对象,根据患者治疗方案将其分为对照组(米非司酮和米索前列醇药物联合宫腔镜下清宫术,n=34)和研究组(甲氨蝶呤宫腔内注射联合宫腔镜下清宫术治疗方案,n=38)。比较两组临床指标、卵巢功能、血管内皮生长因子(vascular endothelial growth factor,VEGF)与血β-人绒毛膜促性腺激素(bloodβ-human chorionic gonadotropin,β-hCG)及临床效果。结果:两组手术时间比较,差异无统计学意义(P>0.05);研究组住院时间、月经恢复时间短于对照组,差异有统计学意义(P<0.05)。两组治疗前卵巢功能、VEGF、β-hCG水平比较,差异无统计学意义(P>0.05);研究组治疗后7 d黄体生成素(luteinizing hormone,LH)、促卵泡激素(follicle-stimulating hormone,FSH)水平高于对照组,雌二醇(estra-diol,E2)、孕激素(progesterone,P4)、孕酮(P)、VEGF、β-hCG水平低于对照组,差异有统计学意义(P<0.05)。研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论:甲氨蝶呤宫腔内注射联合宫腔镜下清宫术治疗CSP患者,更利于卵巢功能恢复,同时还可缩短住院时间,提升治疗效果。
Objective:To explore the clinical effect of intrauterine injection of Methotrexate combined with hysteroscopic curettage in the treatment of cesarean scar pregnancy(CSP).Method:A total of 72 patients with CSP who admitted to the First Integrated Hospital of Traditional Chinese and Western Medicine in Beijing from January 2021 to December 2022 were selected as the research objects,they were divided into the control group(Mifepristone and Misoprostol combined with hysteroscopic curettage,n=34)and the study group(Methotrexate intrauterine injection combined with hysteroscopic curettage,n=38)according to the treatment plan of patients.The clinical indicators,ovarian function,vascular endothelial growth factor(VEGF),bloodβ-human chorionic gonadotropin(β-hCG)and clinical effect were compared between two groups.Result:There was no significant difference in operation time between two groups(P>0.05);the hospitalization time and menstrual recovery time of the study group were shorter than those of the control group,and the differences were statistically significant(P<0.05).There were no significant differences in the ovarian function,VEGF andβ-hCG levels between two groups before treatment(P>0.05);the levels of luteinizing hormone(LH)and follicle-stimulating hormone(FSH)in the study group after 7 d of treatment were higher than those in the control group,and the levels of estradiol(E2),progesterone(P4),progesterone(P),VEGF andβ-hCG were lower than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of treatment in the study group was higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion:Intrauterine injection of Methotrexate combined with hysteroscopic curettage in the treatment of CSP patients is more conducive to the recovery of ovarian function,and it can also shorten the hospitalization time and improve the treatment effect.
作者
孙芸
蔡凤辉
王荣毓
SUN Yun;CAI Fenghui;WANG Rongyu(Beijing Chaoyang District Maternal and Child Health Care Hospital,Beijing 100026,China;不详)
出处
《中外医学研究》
2024年第3期134-137,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
甲氨蝶呤宫腔内注射
宫腔镜下清宫术
子宫瘢痕妊娠
Intrauterine injection of Methotrexate
Hysteroscopic curettage
Cesarean scar pregnancy
