摘要
目的:探究及分析复发性流产患者行低分子肝素联合阿司匹林治疗的效果及对凝血功能与保胎效果的影响。方法:选择2021年1—12月成都市双流区妇幼保健院收治的82例复发性流产患者,根据随机数表法分为对照组和观察组,各41例。对照组给予阿司匹林治疗,观察组给予低分子肝素+阿司匹林治疗。比较两组的保胎效果、不良反应发生率、治疗前后的激素水平[孕酮(P)、雌二醇(E_(2))及β-人绒毛膜促性腺激素(β-h CG)]、凝血相关指标[抗凝血酶Ⅲ(AT-Ⅲ)、纤溶酶原激活剂抑制物-1(PAI-1)、D-二聚体(D-D)]及血栓弹力图指标。结果:观察组保胎成功率显著高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗前,两组激素水平及凝血相关指标比较,差异无统计学意义(P>0.05),妊娠12周及20周时,观察组的P、E_(2)、β-hCG、AT-Ⅲ、PAI-1及D-D均显著优于对照组,差异有统计学意义(P<0.05)。治疗前,两组血栓弹力图指标比较,差异无统计学意义(P>0.05);妊娠12周及20周时,观察组血栓弹力图指标均显著低于对照组,差异有统计学意义(P<0.05)。结论:复发性流产患者行低分子肝素+阿司匹林治疗的效果较好,且可显著改善患者凝血功能。
Objective:To explore and analyze the effect of Low Molecular Weight Heparin combined with Aspirin on coagulation function and miscarriage prevention in patients with recurrent abortion.Method:A total of 82 patients with recurrent abortion admitted to Maternal and Child Health Hospital in Shuangliu District of Chengdu City from January to December 2021 were selected and divided into control group and observation group according to random number table method,with 41 cases in each group.The control group was given Aspirin treatment,and the observation group was given Low Molecular Weight Heparin+Aspirin treatment.The miscarriage prevention effect,incidence of adverse reactions,hormone levels[progesterone(P),estradiol(E_(2))andβ-human chorionic gonadotropin(β-hCG)],coagulation related indexes[antithrombin-Ⅲ(AT-Ⅲ),plasminogen activator inhibitor-1(PAI-1),D-dimer(D-D)]and thromboelastogram indexes before and after treatment were compared between the two groups.Result:The success rate of miscarriage prevention in the observation group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Before treatment,there were no statistically significant differences in hormone levels and coagulation related indexes between the two groups(P>0.05).At 12 and 20 weeks of gestation,the levels of P,E_(2),β-hCG,AT-Ⅲ,PAI-1 and D-D in the observation group were significantly better than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in thromboelastogram indexes between the two groups(P>0.05).At 12 and 20 weeks of gestation,the thromboelastogram indexes in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The effect of Low Molecular Weight Heparin and Aspirin therapy on recurrent abortion is better,and the coagulation function of patients can be significantly improved.
作者
洪长英
HONG Changying(Maternal and Child Health Hospital in Shuangliu District of Chengdu City,Chengdu 610200,China)
出处
《中外医学研究》
2024年第2期10-14,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
低分子肝素
阿司匹林
复发性流产
凝血功能
保胎
Low Molecular Weight Heparin
Aspirin
Recurrent abortion
Coagulation function
Miscarriage prevention
