摘要
目的:妊娠期和产褥期静脉血栓栓塞症(VTE)的防治研究。方法:回顾性分析我院2021年11月至2023年5月我院分娩的产妇160例,根据VTE评分,将评分>2分孕产妇分成A组54例、B组53例、C组53例,A组使用低分子肝素联合下肢气压治疗预防,B组采取双下肢脉冲式动静脉气压治疗(ICPD)预防,C组拒绝采取预防措施;对3组患者血栓前标志物、凝血指标、生活质量进行比较。结果:A组抗凝血酶Ⅲ(AT-Ⅲ)、血浆蛋白C(PC)、蛋白S(PS)水平较B、C组高,D-二聚体(D-D)较B、C组低(P<0.05);A组血浆凝血酶原时间(PT)、活化部分凝血活酶原时间(aPTT)、纤维蛋白原(Fbg)水平较B、C组低,凝血酶时间(TT)水平较B、C组高(P<0.05);A组WHO生活质量量表(WHOQOL-BREF)各维度评分较B、C组高(P<0.05)。结论:科学有效的妊娠期和产褥期VTE的防治措施可有效改善血栓前标志物、凝血指标水平,降低VTE发生的风险,进而提高生活质量,值得推广。
Objective:To study the prevention and treatment of VTE during pregnancy and puerperal period.Methods:A retrospective analysis was performed on 160 parturient women who gave birth in our hospital from November 2021 to May 2023.According to the VTE score,the parturient women with scores>2 were divided into group A(54 cases),group B(53 cases)and group C(53 cases).Group A was treated with low molecular weight heparin combined with lower extremity pressure for treatment and prevention.Group B was treated with pulsed arteriovenous barotherapy(ICPD),group C refused to take any preventive measures.The pre-thrombotic markers,coagulation indexes and quality of life were compared between the three groups.Results:The levels of antithrombinⅢ(AT-Ⅲ),plasma protein C(PC),and protein S(PS)in group A were higher than those in groups B and C,while D-dimer(D-D)was lower than those in groups B and C(P<0.05);The plasma prothrombin time(PT),activated partial thromboplastin time(aPTT),and fibrinogen(Fbg)levels in group A were lower than those in groups B and C,while the thrombin time(TT)levels were higher than those in groups B and C(P<0.05);The WHO Quality of Life Scale(WHOQOL-BREF)scores in all dimensions in Group A were higher than those in Groups B and C(P<0.05).Conclusion:Scientific and effective prevention and treatment of VTE during pregnancy and puerperal period can effectively improve the level of pre-thrombotic markers and coagulation indexes,reduce the risk of VTE occurrence,and then improve the quality of life,which is worth promoting.
作者
曾宇雅
谢清娥
陈雁辉
Ceng Yuya(Meizhou maternal and child health care hospital,Meizhou Guangdong 514000)
出处
《黑龙江医药》
CAS
2024年第1期16-19,共4页
Heilongjiang Medicine journal
基金
梅州市社会发展科技计划项目(项目编号:2022C0301090)。
关键词
血栓前标志物
凝血指标
VTE发生率
生活质量
Prethrombotic Markers
Coagulation Index
Incidence of VTE
Quality of Life
