摘要
目的胺碘酮是最常用的抗心律失常药物,间质性肺炎是其严重不良反应,本研究探讨胺碘酮致弥漫性间质性肺炎的临床特点及治疗预后。方法回顾性分析1例胺碘酮致弥漫性间质性肺炎的临床表现、影像特点、治疗及转归。结果本研究1例高龄男性患者,使用胺碘酮1.5个月后出现咳嗽、呼吸困难,病程发展迅速,快速出现Ⅰ型呼吸衰竭,经对症处理、停用胺碘酮、给予无创呼吸机辅助呼吸、激素等治疗后,临床症状消失。结论胺碘酮致弥漫性间质性肺炎的诊断应根据用药史、结合临床及影像学表现。治疗中应及时停用胺碘酮,对重症患者给予激素、呼吸机的使用是治疗成功的关键。
Objective Amiodarone is the most commonly used antiarrhythmic drug,and interstitial pneumonia is its serious adverse reaction.This study aims to explore the clinical feature and treatment prognosis of amiodarone-induced diffuse interstitial pneumonia.Methods A case of amiodarone-induced diffuse interstitial pneumonia was retrospectively analyzed in terms of clinical manifestations,imaging feature,treatment and outcome.Results The elderly male patient appeared to have symptoms of cough,dyspnea after use of amiodarone for 1.5 months.The course of disease develops rapidly,followed by type Ⅰ respiratory failure.After symptomatic treatment,withdrawal of amiodarone,non-invasive ventilator assisted breathing,administration of hormones,the clinical symptoms disappeared.Conclusion The diagnosis of amiodarone-induced diffuse interstitial pneumonia should be based on medication history,combined with clinical and imaging findings.The key to successful treatment is to discontinue amiodarone,give corticosteroid and ventilator therapy in severe patients.
作者
张森森
张纳新
ZHANG Sen-sen;ZHANG Na-xin(Department of Respiratory Medicine,The Third Central Hospital of Tianjin,Tianjin 300170,China;Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases,Tianjin 300170,China;Artifical Cell Engineering Technology Research Center,Tianjin 300170,China;Tianjin Institute of Hepatobiliary Disease,Tianjin 300170,China)
出处
《中华养生保健》
2024年第3期1-4,共4页
CHINESE HEALTH CARE
关键词
胺碘酮
间质性肺炎
胺碘酮肺损伤
amiodarone
interstitial pneumonia
amiodarone-induced pulmonary toxicity
