摘要
大量流行病学研究表明大气细颗粒物污染的长期暴露与脑血管、行为障碍、神经退行性疾病等脑部疾病的发生或恶化关系密切,然而,目前关于脑部外源性颗粒态污染物的认识仍近乎“黑箱”状态,这已成为准确认识环境污染对脑部健康风险研究的瓶颈问题.本文综述了当前脑部外源性污染物,特别是颗粒态污染物研究的最新进展,提出基于非靶向分析技术、同位素追踪技术等建立脑部外源性颗粒态污染物识别、表征和溯源的系统研究方法,解析入脑外源性颗粒态污染物信息,追踪典型污染物入脑的暴露途径、跨生物屏障转运、代谢归趋及生命周期.为进一步阐明外源性颗粒态污染物对脑部重要生理功能及生命过程的扰动机制提供方法学支撑和科学支持.
The epidemiological researches have showed that long-term exposure to atmospheric fine particulate matter(PM_(2.5))pollution is an important factor for the occurrence and development of some brain diseases,e.g.,cerebrovascular and behavioral disorders,neurodegenerative diseases.Yet,the specific impact of exogenous particulate pollutants on the brain remains a“black box”,which hinder assessing their brain risks scientifically.Here,we review the recent advances in the analysis of exogenous particulate pollutants in the brain.Moreover,this perspective proposes a comprehensive proposal(e.g.,non-targeted analysis,isotopic fingerprints)for identifying and tracing the exogenous PM in the brain.It is of extremely importance for elucidating the occurrence,exposure pathway,transportation,metabolism,and life cycle of PM in the brain.Hence,this method provides a powerful technological support for probing the disturbance mechanism of PM on some physiological functions and life processes of the brain in future studies.
作者
李翔宇
黄俞铭
李林谦
陆达伟
刘倩
江桂斌
LI Xiangyu;HUANG Yuming;LI Linqian;LU Dawei;LIU Qian;JIANG Guibin(Key Laboratory of Environmental Chemistry and Toxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing,100085,China;University of Chinese Academy of Sciences,Beijing,100049,China;Jianghan University,Wuhan,430056,China)
出处
《环境化学》
CAS
CSCD
北大核心
2024年第1期27-32,共6页
Environmental Chemistry
基金
国家自然科学基金(22222610,22376202,22193051)
中国科学院项目(ZDBS-LY-DQC030)资助。
关键词
脑
外源性污染物
识别
追踪
brain
exogenous pollutants
identification
tracing
