摘要
为探讨急性心肌梗死(AMI)患者血清中K^(+)、Na^(+)、Ca^(^(2+))、Fe^(^(2+))、Mg^(^(2+))含量变化,并研究其与心肌梗死患者之间的关系。选取2022年5月至2023年2月收治的AMI患者37例,同时选取健康体检者35例作为对照组。依据入院时或体检时收集的抽血样本进行临床生化分析,比较两组间血清K^(+)、Na^(+)、Ca^(2+)、Fe^(2+)、Mg^(2+)含量,采用判别方程、主成分分析法(PCA),判断分析哪种金属离子对于心肌梗死的诊断价值大。结果表明,AMI患者的血清中Ca^(2+)和Fe^(2+)含量低于健康对照组,差异具有统计学意义。基于血钙、铁水平两组具有显著性差异,以它们为基础进行判别分析,获得判别函数式。将血清中K^(+)、Na^(+)、Ca^(2+)、Fe^(2+)、Mg^(2+)的数据代入进行PCA,绘制并分析PCA载荷因子图,可以判断发现Fe^(2+)对于诊断的价值最大。AMI患者的血清中Ca^(2+)和Fe^(2+)含量较低,同时Ca^(2+)和Fe^(2+)对于诊断心肌梗死具有临床价值。
To explore the changes in serum of K^(+),Na^(+),Ca ^(2+),Fe ^(2+)and Mg ^(2+)levels in patients with acute myocardial infarction(AMI),and to study their relationship with myocardial infarction patients,37 patients with AMI admitted from May 2022 to February 2023 were selected,while 35 healthy individuals were selected as the control group.Based on blood samples collected during admission or physical examination,clinical biochemical analysis was conducted to compare the serum K^(+),Na^(+),Ca ^(2+),Fe ^(2+)and Mg ^(2+)levels between the two groups.Discriminant equations and principal component analysis(PCA)were used to determine which metal ion had the greatest diagnostic value for myocardial infarction.The results showed that the serum levels of Ca ^(2+)and Fe ^(2+)in patients with myocardial infarction were lower than those of the healthy control group,and it had statistical significance.Based on the significant differences in serum of Ca ^(2+)and Fe ^(2+)levels between the two groups,discriminant analysis was conducted to obtain the discriminant function equation.By substituting the data of K^(+),Na^(+),Ca ^(2+),Fe ^(2+)and Mg ^(2+)in serum for PCA,drawing and analyzing the PCA load factor graph,it can be concluded that Fe ^(2+)had the greatest diagnostic value.The serum levels of Ca ^(2+)and Fe ^(2+)in patients with myocardial infarction were relatively low,and Ca ^(2+)and Fe ^(2+)had clinical value for diagnosing myocardial infarction.
作者
盛大平
汪雅婷
乐建军
张艳丽
江鑫垚
李玉锋
王欣
李超
SHENG Daping;WANG Yating;YUE Jianjun;ZHANG Yanli;JIANG Xinyao;LI Yu-Feng;WANG Xin;LI Chao(Department of Clinical laboratory,the First Affiliated Hospital,Anhui Medical University,Hefei,Anhui 230032,China;Department of Clinical laboratory,the Second Affiliated Hospital,Anhui Medical University,Hefei,Anhui 230601,China;Department of General Medicine,Lu′an City People′s Hospital,Lu′an,Anhui 237008,China;Department of Oncology,the Second Affiliated Hospital,Anhui Medical University,Hefei,Anhui 230601,China;The First Clinical Medical College,Anhui Medical University,Hefei,Anhui 230032,China;Institute of High Energy Physics,Chinese Academy of Sciences,Beijing 100049,China;Department of Chemistry,School of Basic Medical Sciences,Anhui Medical University,Hefei,Anhui 230032,China)
出处
《中国无机分析化学》
CAS
北大核心
2024年第1期112-116,共5页
Chinese Journal of Inorganic Analytical Chemistry
基金
国家自然科学基金资助项目(11975247)
安徽省转化医学研究所研究基金资助项目(2022zhyx-C77)
安徽医科大学校科研基金资助项目(2021xkj032)。
关键词
心肌梗死
金属组学
早期诊断
myocardial infarction
metallomics
early diagnosis
