摘要
目的 探讨门冬胰岛素联合二甲双胍对妊娠期糖尿病(gestaional diabetes mellitus, GDM)患者血糖控制及新生儿结局的影响。方法 回顾性分析2019年4月—2023年4月福州台江医院接诊的70例GDM患者的临床资料,依不同用药方案分为对照组和观察组,单纯门冬胰岛素治疗的35例作对照组,门冬胰岛素联合二甲双胍治疗的35例作观察组,比较两组血糖控制水平、新生儿结局、不良反应发生情况。结果 治疗后,观察组空腹血糖(fasting plasma glucose, FPG)、餐后2 h血葡萄糖(2-hour plasma glucose, 2 hPG)为(4.75±0.61)、(6.26±0.81)mmol/L,低于对照组的(5.23±0.86)、(7.82±1.04)mmol/L,差异有统计学意义(t=2.693、7.000,P<0.05)。观察组巨大儿、胎儿窘迫发生率为2.86%,低于对照组的22.86%,差异有统计学意义(χ^(2)=6.248,P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论 门冬胰岛素联合二甲双胍治疗GDM的血糖控制效果理想,可降低新生儿不良结局的发生,具有较高的安全性。
Objective To investigate the effects of insulin aspartate combined with metformin on blood glucose control and neonatal outcomes in patients with gestaional diabetes mellitus(GDM).Methods The clinical data of 70 GDM patients admitted to Fuzhou Taijiang Hospital from April 2019 to April 2023 were retrospectively analyzed,and they were divided into control group and observation group according to different medication regimen.The control group was 35 cases treated with insulin aspartate alone,and the observation group was 35 cases treated with insulin aspartate combined with metformin.Blood glucose control,neonatal outcomes and adverse reactions were compared between the two groups.Results After treatment,fasting blood glucose(FPG)and 2-hour plasma glucose(2 hPG)after meals were(4.75±0.61)mmol/L and(6.26±0.81)mmol/L in observation group,which were lower than(5.23±0.86)mmol/L and(7.82±1.04)mmol/L of control group,and the differences were statistically significant(t=2.693,7.000,P<0.05).The incidence of fetal distress in the observation group(2.86%),was lower than that in the control group(22.86%),and the difference was statistically significant(χ^(2)=6.248,P<0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups(P>0.05).Conclusion Insulin aspartate combined with metformin in the treatment of GDM has ideal blood glucose control effect,can reduce the occurrence of neonatal adverse outcomes,and has a high safety.
作者
李福霞
谢秋燕
陈明
LI Fuxia;XIE Qiuyan;CHEN Ming(Department of Obstetrics and Gynecology,Fuzhou Taijiang Hospital,Fuzhou,Fujian Province,350004 China;Department of Laboratory,Fuzhou Taijiang Hospital,Fuzhou,Fujian Province,350004 China)
出处
《糖尿病新世界》
2023年第23期59-62,共4页
Diabetes New World Magazine
关键词
门冬胰岛素
妊娠期糖尿病
血糖
新生儿结局
安全性
Insulin aspartate
Gestational diabetes mellitus
Blood glucose
Neonatal outcome
Security
