摘要
Ca^(2+)是细胞内浓度变化最大的二价阳离子,参与多种生理过程,常作为信号通路中的第二信使。特异性可原位检测Ca^(2+)的方法引发了大量的研究兴趣,取得了不错的进展。其中基于小分子荧光探针的方法具有探针尺寸小、适用原位监测、生物兼容性高等优点备受关注。总结了近年来基于罗丹明、香豆素等小分子为荧光团的Ca^(2+)荧光探针,希望为未来性能更卓越的红外钙离子荧光探针提供强有力的结构活性基础。
Calcium ions(Ca^(2+))play a crucial role in various biological processes and often serve as important second messengers in signaling pathways due to their large changes in intracellular concentration.Therefore,the development of a specific and reliable method for detecting Ca^(2+)has garnered significant attention.Among the numerous detection methods available,those based on small molecule fluorescent probes have gained prominence due to their advantages such as small probe size,in situ monitoring capability,and excellent biocompatibility.This article provided a systematic overview of fluorescent probes for Ca^(2+)detection in recent years,focusing on probes utilizing rhodamine,coumarin,and other small molecules as fluorophores.By organizing and analyzing the structure-activity relationship of these probes,the article aims to contribute to the further development of near-infrared(NIR)Ca^(2+)probes.
作者
张锡钰
林昕烨
林淑芳
谢妍
李达谅
ZHANG Xi-yu;LIN Xin-ye;LIN Shu-fang;XIE Yan;LI Da-liang(College of Life Sciences,Fujian Normal University,Fuzhou 350117,China)
出处
《化学试剂》
CAS
2024年第2期1-9,共9页
Chemical Reagents
基金
福建省自然科学面上基金项目(2021J01205)。
