摘要
目的 探讨加味补中益气汤对脾胃虚弱型HP阳性慢性萎缩性胃炎患者的临床疗效。方法 132例患者随机分为对照组和观察组,每组66例,对照组给予常规治疗,观察组在对照组基础上加用加味补中益气汤,疗程12周。检测临床疗效、HP清除率、miR-32、TGF-β1、IL-6、PGⅠ、PGⅡ、EGF、生长抑素、胃泌素、胃动素、胃镜病理评分、中医证候评分变化。结果 观察组总有效率、HP清除率高于对照组(P<0.05)。治疗后,2组miR-32、TGF-β1、IL-6、胃镜病理评分、中医证候评分降低(P<0.05),PGⅠ、PGⅡ、EGF、生长抑素、胃泌素、胃动素升高(P<0.05),以观察组更明显(P<0.05)。结论 加味补中益气汤可减轻脾胃虚弱型HP阳性慢性萎缩性胃炎患者炎症反应,调节胃肠激素水平,改善症状,提高疗效。
AIM To explore the clinical effects of Supplemented Buzhong Yiqi Decoction on patients with HP-positive chronic atrophic gastritis of Spleen-Stomach Deficiency Pattern.METHODS One hundred and thirty-two patients were randomly assigned into control group(66 cases)for 12-week intervention of conventional treatment,and observation group(66 cases)for 12-week intervention of both Supplemented Buzhong Yiqi Decoction and conventional treatment.The changes in clinical effects,HP clearance rate,miR-32,TGF-β1,IL-6,PGⅠ,PGⅡ,EGF,somatostatin,gastrin,motilin,gastroscopy pathological score and TCM symptom score were detected.RESULTS The observation group demonstrated higher total effective rate and HP clearance rate than the control group(P<0.05).After the treatment,the two groups displayed decreased miR-32,TGF-β1,IL-6,gastroscopy pathological score,TCM symptom score(P<0.05),and increased PGⅠ,PGⅡ,EGF,somatostatin,gastrin,motilin(P<0.05),especially for the observation group(P<0.05).CONCLUSION For the patients with HP-positive chronic atrophic gastritis of Spleen-Stomach Deficiency Pattern,Supplemented Buzhong Yiqi Decoction can alleviate inflammation,regulate gastrointestinal hormone levels,improve symptoms,and enhance efficacy.
作者
甘辉虎
金连宁
黄红根
周文博
GAN Hui-hu;JIN Lian-ning;HUANG Hong-gen;ZHOU Wen-bo(Xinyu Municipal Hospital of Traditional Chinese Medicine,Xinyu 338025,China)
出处
《中成药》
CAS
CSCD
北大核心
2024年第2期469-473,共5页
Chinese Traditional Patent Medicine
基金
江西省中医药科研课题(2019A486)。
关键词
补中益气汤
常规治疗
HP阳性慢性萎缩性胃炎
脾胃虚弱
Buzhong Yiqi Decoction
conventional treatment
HP-positive chronic atrophic gastritis
Spleen-Stomach Deficiency
