摘要
目的探讨孕早期血清游离三碘甲状腺原氨酸(FT_(3))/FT_(4)对妊娠合并甲状腺功能减退(甲减)患者母婴结局的影响。方法选择122例妊娠合并甲减患者为甲减组,同期产检健康孕妇150例为健康组,甲减组根据母婴结局分为结局良好组和结局不良组,比较各组血清FT_(3)、FT_(4)、FT_(3)/FT_(4)。Logistic多因素回归分析母婴结局的影响因素;ROC评估FT_(3)、FT_(4)及FT_(3)/FT_(4)对母婴结局的预测价值。结果血清FT_(3)、FT_(4)及FT_(3)/FT_(4)甲减组低于健康组,结局不良组低于结局良好组(P<0.05)。体质指数、流产史、FT_(3)、FT_(4)、FT_(3)/FT_(4)是妊娠合并甲减患者母婴不良结局的危险因素(P<0.05)。FT_(3)/FT_(4)预测妊娠合并甲减患者母婴结局的效能高于FT_(3)、FT_(4)(P<0.05)。结论FT_(3)/FT_(4)对妊娠合并甲减患者母婴结局有良好的预测价值,对临床诊疗具有指导作用。
Aim To explore the effect of serum free triiodothyronine(FT_(3))/FT_(4)in early pregnancy on maternal and infant outcomes in patients with gestational hypothyroidism(hypothyroidism).Methods 122 pregnant women with hypothyroidism were selected as the hypothyroidism group,and 150 healthy pregnant women who underwent prenatal examinations during the same period were selected as the healthy group.The hypothyroidism group was divided into a good outcome group and a poor outcome group based on maternal and infant outcomes.The serum FT_(3),FT_(4),and FT_(3)/FT_(4)levels in each group were compared.Logistic multiple regression analysis was used to analyze the influencing factors on maternal and infant outcomes.ROC was used to evaluate the predictive value of FT_(3),FT_(4),and FT_(3)/FT_(4)on maternal and infant outcomes.Results The serum levels of FT_(3),FT_(4),and FT_(3)/FT_(4)in the hypothyroidism group were lower than those in the healthy group,while those in the poor outcome group were lower than those in the good outcome group(P<0.05).BMI,history of miscarriage,FT_(3),FT_(4),and FT_(3)/FT_(4)are risk factors for adverse maternal and infant outcomes in pregnant women with hypothyroidism(P<0.05).The efficacy of FT_(3)/FT_(4)in predicting maternal and infant outcomes in pregnant women with hypothyroidism was higher than that of FT_(3)and FT_(4)(P<0.05).Conclusion FT_(3)/FT_(4)have good predictive value for maternal and infant outcomes in pregnant women with hypothyroidism,and have guiding significance for clinical diagnosis and treatment.
作者
丁永霞
金晶
DING Yongxia;JIN Jing(Obstetrics and Gynecology,Nanjing Maternal and Child Health Hospital,Nanjing 210000,Jiangsu,China)
出处
《中南医学科学杂志》
CAS
2024年第1期87-90,共4页
Medical Science Journal of Central South China
基金
江苏省卫健委科研项目(K2019014)。
