摘要
目的探讨宁夏大学生示指和环指指长比(2D∶4D)与同源盒(HOX)A11基因4个位点(rs6461992、rs6968828、rs7801581、rs17427875)多态性的关联性。方法采用数码相机提取667名宁夏汉族大学生(男性348名,女性319名)手部正面照片,图像分析软件标记解剖点并测量双手示指及环指指长;多重PCR法检测HOXA11基因各位点多态性;统计学软件比较分析2D∶4D和基因多态性在不同性别间的差异及其关联。结果宁夏汉族大学生女性左手和右手2D∶4D均显著高于男性(均P<0.05),右手-左手2D∶4D性别差异不显著;HOXA11基因rs7801581位点基因型、等位基因频率在不同性别间差异显著(均P<0.05),其他位点多态性在性别间的差异均无统计学意义;2D∶4D与HOXA11基因位点多态性关系中,仅女性左手2D∶4D与rs6461992位点基因型显著关联(P<0.05)。结论宁夏汉族大学生2D∶4D性别间差异显著,HOXA11基因rs6461992位点多态性可能与女性2D∶4D的形成有关。
Objective To investigate the association between the index finger and ring finger length ratio(2D∶4D)and of four loci(rs6461992,rs6968828,rs7801581,rs17427875)polymorphism of homeobox(HOX)A11 gene among Ningxia college students.Methods Digit camera was used to collect frontal hand photos of 667 Han college students(348 males and 319 females)from Ningxia province;Image analysis software was used to mark the anatomical points and measure finger lengths of the index and ring fingers of both hands;multiplex PCR was used to detect each locus polymorphisms of HOXA11 gene;statistical software was used to compare and analyze the differences and associations of 2D∶4D and gene polymorphisms between different genders.Results Among Ningxia Han college students,both left hand and right hand 2D∶4D were significantly higher in females than those of in males(all P<0.05),and there were no significant sex differences in right-left hand 2D∶4D;the genotypes and allele frequencies of rs7801581 locus of HOXA11 gene differed significantly between genders(all P<0.05),and none of the other locus polymorphisms showed any significant sex differences;only female left hand 2D∶4D was significantly associated with rs6461992 locus genotype in the relationship between 2D∶4D and HOXA11 polymorphisms(P<0.05).Conclusion There were significant sex differences in 2D∶4D among Han college students in Ningxia,and the rs6461992 locus polymorphism of HOXA11 gene may be associated with the formation of 2D∶4D in females.
作者
杨梦怡
牛世博
张静
党洁
马占兵
陆宏
霍正浩
YANG Meng-yi;NIU Shi-bo;ZHANG Jing;DANG Jie;MA Zhan-bing;LU Hong;HUO Zheng-hao(Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education,Basic Medical College,Ningxia Medical University,Yinchuan 750004,China)
出处
《解剖学报》
CAS
CSCD
2024年第1期62-66,共5页
Acta Anatomica Sinica
基金
国家自然科学基金(32160211)。
