摘要
阿尔茨海默病(Alzheimer’s disease,AD)是一种慢性中枢神经变性疾病,其主要特征是进行性的记忆力减退以及认知障碍,是导致痴呆的主要原因之一。随着全球人口老龄化问题的加剧,AD已经成为本世纪最昂贵,最致命的疾病之一,但目前尚缺乏有效的治疗方法。近年来,多种生物物理刺激技术等非侵入性方法被开发应用于中枢神经系统疾病的治疗,其中包括超声、光、电和磁刺激等,为AD的治疗提供了新的思路。在介绍针对AD的非侵入性多感官刺激治疗(non-invasive multisensory stimulation therapy,NIMST)方法的基础上,综述了这些方法对AD动物模型和AD患者认知功能相关行为表现的影响,以及对改善AD病理的神经机制方面的研究进展。探讨了非侵入性多感官刺激治疗目前的局限性,并对未来的研究方向进行展望,为今后治疗AD提供更有效的治疗策略。
Alzheimer's disease(AD)is a chronic neurodegenerative disorder characterized by progressive memory loss and cognitive impairment,making it one of the leading causes of dementia.With the increasing global aging population,AD has emerged as one of the costliest and deadliest diseases of this century,yet effective treatments are still lacking.In recent years,various non-invasive approaches,including biophysical stimulation techniques,have been developed and applied for the treatment of central nervous system diseases.These techniques involve methods such as ultrasound,light,electrical,and magnetic stimulation,offering new avenues for addressing AD.This article introduces non-invasive multisensory stimulation therapies(NIMST)for AD and reviews their impact on cognitive performance in AD animal models and AD patients,as well as the research progress on the neurobiological mechanisms underlying their potential to ameliorate AD pathology.Finally,the article discusses the current limitations of non-invasive multisensory stimulation therapies and offers insights into future research directions,aiming to provide more effective treatment strategies for AD in the future.
作者
陈晓
赵翠
吕中月
周燕
付帆
励佳熠
赖国钢
杨凯霞
谢国民
Xiao CHEN;Cui ZHAO;Zhongyue LYU;Yan ZHOU;Fan FU;Jiayi LI;Guogang LAI;Kaixia YANG;Guomin XIE(Ningbo Medical Treatment Center Li Huili Hospital,Affiliated with Ningbo University,Ningbo Zhejiang 315201,China)
出处
《阿尔茨海默病及相关病杂志》
2024年第1期77-80,F0003,共5页
Chinese Journal of Alzheimer's Disease and Related Disorders
基金
浙江省重点专科-神经内科(2023SZZ-2)
宁波市重点扶持学科(2022-F05)
卒中后脑功能障碍的风险评估和干预研究,宁波市重点研发专项(2023Z196)。
