摘要
目的观察息风化痰通络颗粒对急性脑梗死患者脂代谢、血液流变学指标及神经功能的影响。方法80例急性脑梗死患者按随机数字表法分为观察组与对照组各40例,对照组采用常规治疗,观察组在对照组基础上予息风化痰通络颗粒治疗。记录并对比分析两组间脂代谢指标[总胆固醇(TC)甘油三酯(TAG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)]、血液流变学指标[全血高切黏度(HSV)、血小板黏附率(PAdR)及红细胞比容(HCT)]、脑血流灌注[大脑中动脉舒张末期血流速度(EDV)、收缩期峰值流速(PSV)及平均血流速度(Vm)]、美国国立卫生研究院卒中量表(NIHSS)评分等。结果治疗后,两组TC、TAG、HDL-C及LDL-C均较治疗前改善(P<0.05),且观察组明显优于对照组(P<0.05);治疗后,两组HSV、PAdR、HCT均较治疗前降低(P<0.05),且观察组明显低于对照组(P<0.05);治疗后,两组EDVPSV及Vm均较治疗前升高(P<0.05),且观察组明显高于对照组(P<0.05);治疗后,两组NIHSS评分均较治疗前降低(P<0.05),且观察组明显低于对照组(P<0.05)。结论息风化痰通络颗粒可改善急性脑梗死患者脂代谢,改善血液流变学指标,增加脑血流灌注,促进神经功能恢复。
Objective:To observe the effects of Xifeng Huatan Tongluo Granules on lipid metabolism,hemorheology,and neurological function in patients with acute cerebral infarction.Methods:A total of 80 patients with acute cerebral infarction were selected and randomly divided into an observation group and a control group,with 40 cases each.The control group received routine treatment,while the observation group received treatment with Xifeng Huatan Tongluo Granules on the basis of the control group.The lipid metabolism indicators[total cholesterol(TC),triglycerides(TAG),high-density lipoprotein cholesterol(HDLC),and low-density lipoprotein cholesterol(LDLC)],blood rheology[whole blood high shear viscosity(HSV),platelet adhesion rate(PAdR),and hematocrit(HCT)],cerebral blood perfusion[middle cerebral artery end-diastolic blood velocity(EDV),peak systolic flow velocity(PSV),and mean blood flow velocity(Vm)],National Institutes of Health Stroke Scale(NIHSS)scores and other levels of the two groups were recorded and compared.Results:After treatment,the levels of TC,TAG,HDLC,and LDLC in both groups improved compared with before treatment(P<0.05),and the observation group was significantly better than the control group(P<0.05);after treatment,the levelsof EDV,PSV and Vm in both group sincreased obvisouly(P<0.05),and the observation group washigher significantly than the controlgroup(P<0.05);after treatment,the levels of HSV,PAdR,and HCT in both groups decreased compared with before treatment(P<0.05),and the observation group was significantly lower than the control group(P<0.05);after treatment,the NIHSS scores of both groups decreased compared with before treatment(P<0.05),and the observation group was significantly lower than the control group(P<0.05).Conclusion:Xifeng Huatan Tongluo Granules can improve lipid metabolism,improve blood rheology,increase cerebral blood flow perfusion,and promote neurological function recovery in patients with acute cerebral infarction.
作者
方美凤
谭峰
曹冰倩
Fang Meifeng;Tan Feng;Cao Bingqian(Foshan Traditional Chinese Medicine Hospital,Guangdong,Foshan 528000,China)
出处
《中国中医急症》
2024年第2期256-259,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
国家自然科学基金项目(81774423)。
关键词
急性脑梗死
息风化痰通络颗粒
脂代谢
血液流变学
脑血流灌注
神经功能
Acute cerebral infarct
Xifeng Huatan Tongluo Granules
Lipid metabolism
Hemorheology
Brain perfusion
Neurological function
