摘要
目的观察半夏泻心汤联合四联疗法对急性胃溃疡患者胃黏膜保护作用、胃肠道菌群分布及氧化应激反应的影响。方法将急性胃溃疡患者86例按照随机数字表法分为对照组与观察组各43例。对照组予以幽门螺杆菌四联治疗,观察组在对照组基础上,根据名老中医马万千主任医师的临床经验予以半夏泻心汤治疗。比较两组临床疗效、胃黏膜保护因子水平、氧化应激反应及胃肠道菌群分布。结果研究中两组剔除、脱落共3例,最终共纳入病例83例,对照组41例,观察组42例。观察组总有效率为92.86%,高于对照组的75.61%(P<0.05);观察组治疗后胃蛋白酶原Ⅰ(PGⅠ)水平较对照组高,胃蛋白酶原Ⅱ(PGⅡ)水平较对照组低(P<0.05);观察组治疗后超氧化物歧化酶(SOD)水平较对照组高,一氧化氮(NO)、丙二醛(MDA)水平较对照组低(P<0.05);观察组治疗后肠球菌、肠杆菌数量较对照组少,双歧杆菌、乳酸杆菌数量较对照组多(P<0.05)。结论半夏泻心汤联合四联疗法可保护急性胃溃疡患者胃黏膜、调节胃肠道菌群分布,减轻氧化应激反应,疗效显著。
Objective:To investigate the effects of Banxia Xiexin Decoction combined with quadruple therapy on gastric mucosa protection,gastrointestinal flora distribution and oxidative stress response in patients with acute gastric ulcer.Methods:A total of 86 patients with acute gastric ulcer admitted were selected and divided into control group and observation group(43 cases each)according to random number table method.The control group was treated with quadruple Helicobacter pylori,and the observation group was treated with Banxia Xiexin Decoction according to the clinical experience of the famous old Chinese medicine chief doctor Ma Wanqian.The clinical efficacy,gastric mucosal protective factor level,oxidative stress response and gastrointestinal flora distribution were compared between the two groups.Results:In the study,a total of 3 cases were removed and dropped out from the two groups,and a total of 83 cases were finally included,including 41 cases in the control group and 42 cases in the observation group.The total effective rate of observation group was 92.86%,which was higher than 75.61%of the control group(P<0.05).The level of pepsinogenⅠ(PGⅠ)in the observation group was higher than that in the control group,but the level of pepsinogenⅡ(PGⅡ)was lower than that in the control group(P<0.05).After treatment,the level of superoxide dismutase(SOD)in observation group was higher than that in con-trol group,and the levels of nitric oxide(NO)and malondialdehyde(MDA)were lower than that in control group(P<0.05).After treatment,the number of enterococcus and Enterobacterium in observation group was less than that in control group,while the number of bifidobacterium and lactobacillus was more than that in control group(P<0.05).Conclusion:Banxia Xiexin Decoction combined with quadruple therapy can protect gastric mucosa,regulate gastrointestinal flora distribution and reduce oxidative stress in patients with acute gastric ulcer.
作者
邹济源
武琛
谭海成
陈林
焦云涛
左瑞菊
Zou Jiyuan;Wu Chen;Tan Haicheng;Chen Lin;Jiao Yuntao;Zuo Ruiju(Bejing Hospital of Traditional Chinese Medicine Shunyi Hospital,Beijing 101300,China)
出处
《中国中医急症》
2024年第2期284-287,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
马万千全国基层名老中医药专家传承工作室(国中医药人教教育便函[2017]325号)。
关键词
急性胃溃疡
半夏泻心汤
胃肠道菌群
氧化应激
胃黏膜
Acute gastric ulcer
Banxia Xiexin Decoction
Gastrointestinal flora
Oxidative stress
Gastric mucosa
